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| 基于薄层CT扫描大数据的骨结构常规分析 |
| Analysis of bone structure based on a large dataset of thin layer CT scanning |
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| DOI：10.3969/j.issn.1006-7108.2016.10.007 |
| 中文关键词: 薄层CT扫描 骨结构 骨密度 骨质疏松症 大数据 |
| 英文关键词:Thin layer CT scanning Bone Structure Bone Density Osteoporosis Large dataset |
| 基金项目:福建省科技厅计划项目（2014J01377）；福建省科技厅计划项目（2013J01391）；
福建省莆田市科技局计划项目（2012S03(4)） |
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| 中文摘要: |
| 目的 骨密度降低和骨结构劣化是骨质疏松症发生病理性骨折的根本原因，因此，准确、快速判断骨结构优劣具有重要的诊断及骨折风险评估价值。此研究通过薄层CT扫描大数据的描述性统计学分析，命名为“骨结构常规”，探讨量化判断骨结构优劣的可行性。
方法 721例薄层CT扫描数据，在Mimics 14.0以三维分割的方式将股骨分割为股骨头、股骨颈和转子间三个部分，并且加入一步随意分割股骨颈的步骤。通过Excel宏命令获得数据：①CT值平均值： ；②标准差系数：Vσ（σ/ ）。统计学分析：①年龄与 ,Vσ的相关及回归分析。②股骨头、股骨颈、转子间部分与年龄相关性的比较。③随意分割的股骨颈与准确切割的股骨颈之间的单因素方差分析。结果 相关分析：①年龄与松质骨及完整股骨的 呈负相关，松质骨R2为0.799-0.8278，完整股骨R2为0.7951-0.8251；②年龄与松质骨及完整股骨的Vσ呈正相关，松质骨R2为0.8829~0.9411，完整股骨R2为0.8381~0.8839；③年龄与松质骨的相关性优于完整股骨。相关性比较：股骨颈与年龄的相关性高于股骨头与转子间部分。单因素方差分析：随意分割的股骨颈与准确分割的股骨颈相比较，在松质骨部分二者的CT值均值和标准差系数并无显著差异。结论 骨结构常规具有良好的质量控制，可用于量化判断骨结构优劣。 |
| 英文摘要: |
| Objective Bone mineral density and bone structural deterioration are the fundamental causes of pathological fracture in osteoporosis. Therefore, accurate and rapid assessment of the quality of bone structure has important value for diagnosis and fracture risk assessment. This study was based on the descriptive statistics of a large dataset of thin layer CT scanning, namely Bone structure Convention, to explore the feasibility of quantitative judgment of bone structure assessment. Method Thin layer CT scanning data of 721 cases were included in this analysis. Femur was divided into three sections: femoral head, neck of femur and intertrochanter using Mimics 14.0, followed by step by step split of the neck of the femur. The following data were obtained by Excel macro command: ①②③④ Mean value of CT: ; ② Standard deviation coefficient: Vσ (σ/ ). Statistical analysis: ① Correlation and regression analysis of age and , Vσ. ②Correlation comparison of age and femoral head, femoral neck and intertrochanter. ③ Single factor analysis of variance between randomly divided femoral neck and accurate segmentation of femoral neck. Result Correlation analysis: ①Age was negatively correlated with of cancellous bone and intact femur, R2 for cancellous bone was 0.799~0.8278, R2 for intact femur was 0.7951-0.8251. ② Age was positive correlated with Vσ of cancellous bone and intact femur, R2 for cancellous bone was 0.8829~0.9411, R2 for Intact femur was 0.8381-0.8839. ③ The correlation between age and cancellous bone was better than that of intact femur. Correlation comparison: the correlation between femoral neck and age was higher than that of femoral head and intertrochantor. Single factor variance analysis: for the comparison of randomly divided femoral neck and accurate segmentation of the femoral neck, there were no significant differences in the mean value of CT and standard deviation coefficient for the cancellous bone. Conclusion Routine bone structure assessment has good quality control, and can be used to determine the quality of bone structure. |
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