| Objective To investigate bone mineral density (BMD) in patients with maintenance hemodialysis (MHD) and peritoneal dialysis(PD) in our hospital, and to understand the risk factors of abnormal bone quantity in patients undergoing MHD and PD. Methods Inpatients and outpatients satisfying the inclusion criteria of dialysis for > 3 months were included (237 MHD and 206 PD cases). Clinical and laboratory parameters were collected, and calcaneal quantitative ultrasounds (QUS) were used to assess bone mineral density in MHD and PD patients. Correlation analyses were performed to assess relationships between clinical and laboratory data. Risk factors analyses for bone abnormalities in dialysis patients were also performed. The SPSS 19.0 software package was used for these statistical analyses. Results The incidence of abnormal bone quantity was significantly greater in MHD (57.98%) versus PD (48.54%) patients (P=0.005). The overall incidence of abnormal bone quantity increased with increasing dialysis durations. Dialysis duration, serum ALP, phosphorus and bone mineral density in dialysis patients had close correlation, P<0.05. Risk factors for abnormal bone quantity include older age, prolonged dialysis duration, increased BMI, ALP and phosphorus levels. Conclusion The incidence of abnormal bone quantity in MHD patients was greater than that of PD patients, and, MHD patients were more prone to have reduced bone mineral density. Bone density of dialysis patients decreases with prolonged dialysis duration. Older age, prolonged dialysis duration, phosphorus and ALP are all risk factors for abnormal bone quantity in dialysis patients. |