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| 复方贞术调脂胶囊对糖皮质激素诱导骨质疏松大鼠血脂和骨转换指标的研究 |
| Effects of FTZ on blood lipids and bone turnover markers in glucocorticoid-treated rats |
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| DOI：10.3969/j.issn.1006-7108.2016.10.017 |
| 中文关键词: 糖皮质激素 复方贞术调脂胶囊 血脂 骨转换 骨质疏松 |
| 英文关键词:Glucocorticoid FTZ Blood lipid Bone turnover markers Osteoporosis |
| 基金项目:广东省科技计划项目（2016A030303061） |
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| 中文摘要: |
| 目的 观察复方贞术调脂胶囊(FTZ)对糖皮质激素诱导骨质疏松大鼠血脂水平和血清骨转换指标的影响。方法3月龄SPF级雄性SD大鼠32只，随机等分为4组：Nrm组为正常对照组，Met组为皮下注射甲强龙(Met) 5mg/(kg?d)，每周5次，FTZL组和FTZH组在Met组基础上每日分别给予低剂量FTZ(1.5g/kg)和高剂量FTZ(6g/kg)灌胃，实验期为12w。ELISA 法测量血脂四项(TC、TG、HDL-C、LDL-C)，血清中Ⅰ型前胶原氨基末端前肽(N-terminal propeptide of type I procollagen，PINP)、Ⅰ型胶原羧基端肽(C-terminal cross- linking telopeptide of type I collagen，β-CTX)和OC(osteocalcin)含量。结果 Met组大鼠体质量、血清HDL和OC、P1NP均显著低于Nrm组相应指标(Ρ﹤0.05, Ρ﹤0.01, Ρ﹤0.001)，血清TC、TG、LDL和β-CTX显著高于Nrm组(Ρ﹤0.01)；FTZL组大鼠的体质量和P1NP较Met组有升高趋势，β-CTX有降低趋势，但两组间各指标均无显著性差异(Ρ﹥0.05)；FTZL组大鼠血清HDL和OC显著高于Met组(Ρ﹤0.05)，血清TC、TG和LDL显著低于Met组(Ρ﹤0.05)；FTZH组大鼠体质量、血清HDL、OC和P1NP显著高于Met组相应指标(Ρ﹤0.001, Ρ﹤0.01, Ρ﹤0.05)，血清TC、TG、LDL和β-CTX显著低于Met组(Ρ﹤0.05)；FTZH组大鼠血清TC、HDL、LDL和OC显著高于FTZL组(Ρ﹤0.05, Ρ﹤0.01)。结论 FTZ对糖皮质激素诱导骨质疏松大鼠的血脂和骨转换有一定的改善作用。 |
| 英文摘要: |
| Objective To study the effects of FTZ on blood lipids and bone turnover markers in glucocorticoid-treated rats. Method Thirty two male SD rats at the age of 3 months were randomized into four groups: age-matched normal control (Nrm), methylprednisolone (Met) (5.0mg/kg, sc, per day for 5 days/week), Met plus FTZL gavage administration (1.5g/(kg?d)) and Met plus FTZH gavage administration (6 g/(kg?d)). The study period was 12 weeks. The serum levels of TC, TG, HDL-C, LDL-C, N-terminal propeptide of type 1 procollagen (P1NP)、C-terminal cross- linking telopeptide of type I collagen (β-CTX) and Osteocalcin (OC) were assessed using ELISA. Result Met had significantly lower body weight, HDL, OC, P1NP (Ρ﹤0.05, Ρ﹤0.01, Ρ﹤0.001) than Nrm, and Met had significantly higher TC, TG, LDL and β-CTX) (Ρ﹤0.01). There were no significant differences between Met and FTZL in body weight, P1NP and β-CTX (Ρ﹥0.05), but FTZL had significantly higher HDL and OC (Ρ﹤0.05), and significantly lower TC, TG and LDL (Ρ﹤0.05) than Met. FTZH had significantly higher body weight, HDL, OC and P1NP (Ρ﹤0.05, Ρ﹤0.01, Ρ﹤0.001), and significantly lower TC、TG、LDL and β-CTX (Ρ﹤0.05) than Met. FTZH had significantly higher TC, HDL, LDL and OC (Ρ﹤0.05, Ρ﹤0.01) than FTZL. Conclusion FTZ had active effect in the blood lipid and bone turnover markers in glucocorticoid-treated rats. |
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