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| 野葛叶总黄酮提取物对去卵巢大鼠骨质疏松的防治作用 |
| The therapeutic effect of extracts of Kudzu leaf flavonoids on osteoporosis in ovariectomized rats |
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| DOI：10.3969/j.issn.1006-7108.2016.10.018 |
| 中文关键词: 野葛叶 总黄酮 骨质疏松 |
| 英文关键词:Kudzu leaf Total flavonoids Osteoporosis |
| 基金项目:2014年浙江省大学生科技创新活动计划（2014R433007） |
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| 中文摘要: |
| 目的 探讨野葛叶总黄酮提取物对去卵巢大鼠骨质疏松的防治作用。方法 选择6月龄SD雌性大鼠60只，随机分为假手术组、模型组、己烯雌酚组、野葛叶总黄酮提取物低和高剂量组。观察各组胫骨抗弯力，右股骨和腰4椎体的骨密度和骨生物力学性能，血清中钙（Ca）、磷（P）和碱性磷酸酶（ALP）的变化。结果 野葛叶总黄酮高、低剂量组及己烯雌酚组大鼠胫骨抗弯力，股骨和腰椎的骨生物力学性能均高于模型组（P<0.05）；野葛叶总黄酮高剂量组及己烯雌酚组大鼠股骨和腰椎骨密度，ALP的变化均高于模型组（P<0.05）。结论 野葛叶总黄酮提取物通过提高大鼠胫骨抗弯力，增加股骨和腰椎的骨密度，改善股骨和腰椎的骨生物力学性能，提高血清ALP含量等因素防治骨质疏松。 |
| 英文摘要: |
| Objective To investigate the therapeutic effect of extracts of Kudzu leaf flavonoids (EKLF) on osteoporosis in ovariectomized rats. Methods A total of 60 adult female SD rats were randomly assigned to 5 groups: sham operation group, ovariectomized group, diethylstilbestrol group, low dose EKLF group, and high dose EKLF group. The bending force of tibia, bone mineral density of the right femur and the 4th lumbar vertebra and bone biomechanical characteristics were determined. The serum levels of calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) were also measured. Results The bending force of tibia and all the biomechanical parameters in high and low dose EKLF groups and the diethylstilbestrol group were higher than those in the ovariectomized group (P<0.05). Bone mineral density of the lumbar vertebra and the right femur and the serum levels of ALP in the high dose EKLF group and diethylstilbestrol group were significantly higher than those in the ovariectomized group (P<0.05). Conclusion EKLF has therapeutic effect on osteoporosis by enhancing the bending force of tibia, increasing bone mineral density of the lumbar vertebrae and the femur, improving bone biomechanical characteristics and raising the serum levels of ALP. |
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