| Objective In knee osteoarthritis patients, to observe the effects of Shu Jin Jie Gu Tang (SJJGT) on WOMAC osteoarthritis index, joint tenderness, swelling, joint activity and serum tumor necrosis factor (TNF-α), interleukin -1 (IL-1) and changes in transforming growth factor -β (TGF-β) levels, in order to evaluate its clinical efficacy. Methods 132 patients with knee osteoarthritis were divided into control group and treatment group, with 66 cases in each group. Controls were given oral glucosamine sulfate, and the treatment group oral SJJGT. Four weeks after treatment, comparisons between the two groups of patients were made on changes of WOMAC osteoarthritis index, joint tenderness, swelling, and changes in activity and serum TNF-α, IL-1, TGF-β levels. Results After 4 weeks, the treatment group compared with the control group had significantly lower WOMAC index, VAS score, joint tenderness, swelling and joint activity scores (P<0.05), significantly lower TNF-α and IL-1 (P<0.05), but significantly higher serum TGF-β (P<0.05).Conclusion FYJGT showed a significant effect on knee joint osteoarthritis, and can effectively restrain joint inflammation, reduce joint destruction, and alleviate clinical symptoms. |