| Osteoporosis is becoming one of the major diseases in old age. It affects the health of the elderly, and was caused by greater bone absorption than bone formation. Current research is focused on regulating bone anabolic signal transduction pathways, inhibiting osteoclast bone absorption, and reduce bone remodeling to reduce bone loss. This article summarizes bone metabolism related regulation pathways, including the MAPK signal transduction pathways, Notch signal pathway, Wnt/decide- catenin signaling pathways, BMPs signaling pathways, PPAR-r signaling pathways, TGF-decide signaling pathways and Hedgehog signal transduction pathways. Multiple signaling pathways cross each other, participate in the regulation of relevant factors in the pathways, through activating or inhibiting cytokines at some key links, and play a major role in bone metabolism. |