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| Ward区的随访研究 |
| Follow up study of the Ward region |
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| DOI：10.3969/j.issn.1006.7108.2016.11.008 |
| 中文关键词: 骨密度 Ward区 X线 |
| 英文关键词:Bone mineral density Ward region X-ray |
| 基金项目:清华大学医院科学研究基金（110200004) |
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| 中文摘要: |
| 目的 深入研究Ward区做为骨密度随访指标的临床意义。方法 采用美国Norland XR-600双能X线骨密度仪,通过测定58例骨质疏松或骨量减少患者6个月内左股骨近端、正位腰椎、全身骨密度，观察股骨颈、Ward区、L2-4、全身骨密度 (BMD)及骨矿含量与瘦体重的百分比（％TBMC/FFM)随时间的变化规律及临床特点；通过测定58例患者血钙、血磷、碱性磷酸酶等生化指标，分析其与骨密度的相关性。结果 ①所有患者全身BMD降低,％TBMC/FFM低于5%或为正常低值。②服药治疗组6个月后Ward区BMD显著增加，P = 0. 0028,P <0. 05，差异有统计学意义；股骨颈、L2-4、全身BMD、％ TBMC/FFM变化量的P值均大于0.05，差异无统计学意义；未服药组所有观测部位BMD变化均无统计学意义（P >0.05)。③所有患者血钙、血磷、碱性磷酸酶（ALP)等生化指标无明显改变（P >0.05)。结论 Ward区对骨密度变化敏感性高，做为骨质疏松患者的临床随访指标，优于其他部位的骨密度测量。 |
| 英文摘要: |
| Objective To further study the clinical significance of Ward region as a bone mineral density (BMD) follow up index. Methods BMD of the femoral neck, Ward region, L2-4 , whole body, and the ratio of bone mineral content and lean body mass percentage (% TBMC/FFM) with time in 58 cases of osteoporosis was determined using dual-energy X-ray absorptiometry (DXA, Norland XR-600) in 6 months. Serum levels of calcium, phosphorus, and alkaline phosphatase were examined. The correlation between them and BMD was analyzed. Results 1 ) The whole body BMD decreased and % TBMC/FFM was lower than 5% or lower-normal value in all patients. 2) BMD of Ward region significantly increased (P = 0. 0028，P < 0. 05 ) , but BMD of the femoral neck, L2-4, whole body, and % TBMC/FFM was not significantly changed (P > 0. 05) in medication group in 6 months. BMD of all observed parts was no significantly changed in non-medication group (P > 0.05). 3) Serum calcium， phosphorus, and alkaline phosphatase were not significantly changed in all patients (P > 0. 05). Conclusion BMD of Ward region was more sensitive as clinical follow up index than that of other parts in patients with osteoporosis. |
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