Objective To evaluate the status of bone mineral density (BMD) in older male patients with megaloblastic anemia (MA). Methods A total of 40 patients diagnosed as MA admitted to the Osteoporosis Department of the 309 Hospital from January 2010 to January 2016, aged 62 to 86 (73. 50 ±8. 13) years, were select as the research group. Another 40 healthy people undergone physical examination at the physical examination center during the same time period, with an average age of (72. 82±7. 77) years,were selected as the control group. BMD of L1 -L4 and hip ( femoral neck region) was measured using dual energy X- ray absorptiometry ( DXA, HOLOGIC,USA). Height, weight, and serum AST, ALT, BUN, CRE, homocysteine ( Hcy), cyanocobalamin (Vit B12) , folic acid were measured in both groups. Results BMD and the levels of folic acid and Vit B12 were significantly lower in the MA group compared with the control group (P< 0. 05),but the levels of Hey were significantly higher than that of the control group (P <0. 05). Conclusion Older male patients with MA were more likely to suffer from osteoporosis, suggesting that MA may be a risk factor for osteoporosis in older male patients. |