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| 维生素D与2型糖尿病患者静力性平衡的相关性分析 |
| Study of the relationship between vitamin D and static equilibrium in patients with type diabetes mellitus |
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| DOI：10.3969/j.issn.1006.7108.2016.12.016 |
| 中文关键词: 维生素D 2型糖尿病；静力性；平衡 |
| 英文关键词:Vitamin D Type 2 diabetes mellitus Static Equilibrium |
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| 中文摘要: |
| 目的 分析2型糖尿病患者不同维生素D水平组之间静力性平衡指标的差异，探讨维生素D对平衡功能的影响。方法 对86名年龄32?78岁的2型糖尿病患者进行研究，测定体重指数、跟骨骨密度、25(OH)D3水平等指标，应用Foot Scan Balance7. 7平板式足底压力测试系统评估静力性平衡功能，获得压力中心的移动轨迹总长度（TTW)及包绕95%压力中心移动轨迹在内的椭圆面积（EA)两项平衡参数，分析维生素D对平衡参数的影响。结果 86名受检者平均年龄（54. 99 ± 10. 19) 岁，男女比例40:46，按照25(OH)D3水平分为3组：严重缺乏组（<10 ng/mL，n = 32);缺乏组（≥10 ng/mL而<20 ng/mL,n= 40);不足组（≥20 ng/ml而<30 ng/mL, n =14）。维生素D严重缺乏组压力中心移动轨迹总长度（TTW)及包绕95%压力中心移动轨迹在内的椭圆面积（EA)明显高于不足组，差异存在统计学意义[(10. 66 ±4. 42) mm对（97. 0 ± 20. 1) mm; (11. 55 ± 8. 78) mm2对（6. 58 ±2. 68)mm2,P<0. 05]。多元逐步回归分析显示25 ( OH)D3 水平与压力中心移动轨迹总长度（TTW)及包绕95%压力中心移动轨迹在内的椭圆面积（EA)成负相关，相关系数分别为-1.835和-0. 247 ,P < 0. 05。且独立于年龄、性别、跟骨骨密度等因素。结论 糖尿病患者中维生素D水平同静力性平衡之间存在独立负相关，对糖尿病患者进行维生素D 的筛查及补充仍有待进一步研究。 |
| 英文摘要: |
| Objective To analyze the difference of static equilibrium index among diverse vitamin D level groups in patients with type 2 diabetes mellitus, and to investigate the relationship between vitamin D and balance function. Methods Eight-six patients with type 2 diabetes were enrolled, aged from 32 to 78 years old. Body mass index ( BMI)，calcaneal bone mineral density (CBMD)，and 25-hydroxy vitamin D (25( OH) D3) levels were measured. The static equilibrium abilities were assessed using flat foot pressure measurement system (Foot Scan Balance7.7). Static equilibrium index included total traveled way of pressure center (TTW) and 95% confidence ellipse area (EA). The effect of vitamin D on equilibrium index was analyzed. Results Forty-six females and 40 males were included in this study. The average age was (54. 99±10. 19) years old. According to the level of 25 (OH)D3, the patients were divided into 3 groups：serious deficiency group ( < 10 ng/ml, n = 32)，deficiency group (≥ 10 ng/ml, <20 ng/ml, n =40)，insufficiency group(≥20 ng/ml, <30 ng/ml, n = 14). The TTW of pressure center and 95% confidence EA in the severe deficiency group were significantly higher than those in the deficiency group. The difference was statistically significant (10.66 ±4. 42 mm vs 97. 0 ± 20. 1 mm，11, 55 ± 8. 78 mm2 vs 6. 58±2, 68 mm2，both P < 0. 05). Multiple stepwise regression analysis showed that the level of 25( OH) D3 was negatively correlated with the TTW of pressure center ( r = - 1. 835，P <0. 05) and 95% confidence EA ( r = - 0. 247，P < 0. 05 ) , and was independent of age, gender, and CBMD. Conclusion There is independent negative correlation between the level of vitamin D and the static equilibrium. The screening and supplementing of vitamin D in patients with type 2 diabetes mellitus still needs further research. |
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