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| OPG/RANK/RANKL系统与原发性骨质疏松症的关联性及补肾活血法的调节作用研究进展 |
| Research progress on the relationship between OPG/RANK/RANKL system and primary osteoporosis and on the regulation effect of invigorating kidney and promoting blood circulation |
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| DOI：10.3969/j.issn.1006.7108.2016.12.021 |
| 中文关键词: 原发性骨质疏松症 OPG/RANK/RANKL系统 补肾活血 中医中药 |
| 英文关键词:Primary osteoporosis OPG/RANK/RANKL system Invigorate kidney and promote blood circulation Traditional Chinese Medicine |
| 基金项目:国家自然科学基金项目（81560780) |
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| 中文摘要: |
| 随着我国社会人口老龄化的到来，罹患原发性骨质疏松症的人将越来越多，加之该病起病隐匿，早期症状不典型，往往到出现严重疼痛甚至发生骨折才得以明确诊断，因此已成为一个全社会性的间题，给个人、家庭以及社会造成严重负担，研究原发性骨质疏松症的治疗意义重大。目前西药治疗该疾病存在很多毒副作用，而中医药对其防治积累了丰富的经验，形成了 一套成熟的理论。本文通过中国知网检索2005年至2016年关于现代医学OPG/RANK/RANKL系统与原发性骨质疏松症的关系及中医补肾活血法治疗原发性骨质疏松症作用的现代研究文献，从中挖掘出OPG/RANK/RANKL系统与原发性骨质疏松症的关联性，以期探讨补肾活血法治疗原发性骨质疏松症的作用途径，为临床提供客观的实验室依据，促进补肾活血法治疗原发性骨质疏松症的临床推广应用。 |
| 英文摘要: |
| With the advancement to the era of population aging, there are more and more primary osteoporosis patients. Since the onset of the disease is not obvious，and early symptoms are not typical，osteoporosis is often only diagnosed after severe pain and even fractures. It has become a problem to the whole society, and brings heavy burden to individuals, families and the society. Therefore research on the treatment of primary osteoporosis is of great significance. Western medicines currently exist have many side effects, whereas the prevention and treatment of osteoporosis using Chinese medicine has accumulated rich experience and formed a set of mature theory. This paper through CNKI retrieval of literature from 2005 to 2016 on the relationship between OPG/ RANK/RANKL system in modern medicine and primary osteoporosis and on the regulation effect of invigorating kidney and promoting blood circulation on primary osteoporosis, evaluated the relevance of OPG/RANK/RANKL system and primary osteoporosis, with the aims of exploring the functional pathway of invigorating kidney and promoting blood circulation, providing objective laboratory evidence for clinical application and promoting the clinical application of invigorating kidney and promoting blood circulation in the treatment of primary osteoporosis. |
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