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| 选择性雌激素受体调节剂对骨关节炎作用的研究进展 |
| Research progresses on the effects of selective estrogen receptor modulators on osteoarthritis |
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| DOI：10.3969/j.issn.1006.7108.2016.12.023 |
| 中文关键词: 骨关节炎 选择性雌激素受体调节剂 关节 雌激素 |
| 英文关键词:Osteoarthritis Selective estrogen receptor modulators Joint Estrogen |
| 基金项目:国家自然科学基金项目（NSFC31171136) |
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| 中文摘要: |
| 目的 综述选择性雌激素受体调节剂（selective estrogen receptor modulators，SERMs)对骨关节炎（osteoarthritis，OA)作用的研究进展。方法 广泛查阅国内外有关雌激素和SERMs对OA作用效果及作用机制的有关文献，并进行综述。结果 SERMs阻止OA软骨和软骨下骨破坏，减轻滑膜炎，维持关节健康，并在一定程度上改善OA样关节退变，延缓OA关节的破坏。结论 SERMs对OA关节具有保护作用，有望成为OA调修药的候选药物，但仍需完善相关的基础和临床研究，明确 SERMs对OA的作用机制。 |
| 英文摘要: |
| Objective To review the research progresses on the effects of selective estrogen receptor modulators (SERMs) on osteoarthritis. Methods The relevant literature on the effects and mechanisms of SERMs on osteoarthritis in recent years was extensively reviewed and comprehensively analyzed. Results SERMs could prevent cartilage and subchondral bone destruction and ameliorate synovitis caused by osteoarthritis，maintain joint health，to some extent reverse OA-like joints change，and delay the destruction of OA joints. Conclusion SERMs have potential protective role on osteoarthritis joints, and have the potential to become candidates for osteoarthritis disease modifying drugs. However, further studies are needed to further clarify the mechanism of SERMs on osteoarthritis. |
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