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| 骨质密度改变与腰椎间盘退变的关系，一项基于18F-FDG标记的PET-CT研究 |
| An analysis of the relationship between bone mineral density and lumbar disc degeneration |
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| DOI：10.3969/j.issn.1006-7108.2017.01.012 |
| 中文关键词: 椎间盘退变 骨质密度 18F-FDG 显像 |
| 英文关键词:IDD BMD 18F-FDG PET-CT imaging |
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| 中文摘要: |
| 目的 通过对临床病例腰椎间盘退变分级与相应骨质密度( bone mineral density，BMD)和平均标准摄取值（standard uptake value，SUV）的分析，推断腰椎间盘退行性变（intervertebral disc degeneration,IDD）与BMD和SUV的关系。方法 以集群抽样的取样方法，从2011年1月至2015年10月于我院行PET-CT检查的5013例病人中，纳入了224例符合标准的病人，年龄在30~87岁之间，其中男性148例，女性76 例。两组性别间年龄无统计学差异。采用西门子PET-CT扫描仪行全身18F-FDG显像，扫描范围：头顶到大腿中部。测量腰3、4、5椎体CT平扫骨质密度，分析在不同性别间L3-4，L4-5椎间盘相关BMD值和SUV值的差异，及其与腰椎间盘退变的关系。结果 L3-4，L4-5椎间盘相关BMD值和SUV值在不同性别间差异没有统计学意义，但是在老年组（年龄在65~87）有显著性差异。老年女性BMD值和SUV值均低于老年男性。IDD组的骨密度值低于非IDD组(P＜0.05)， IDD组的SUV值高于非IDD组(P＜0.05)。各个级别IDD的L3-4和L4-5 BMD值不全相同，整体趋势是随着IDD分级越高，BMD值越低。结论 IDD引起骨质密度值降低，和相应椎体代谢的增高。 |
| 英文摘要: |
| Objective To study the relationship among intervertebral disc degeneration (IDD), bone mineral density (BMD), and standard uptake value (SUV) values, by analyzing the clinical grade of IDD, BMD and SUV. Methods A total of 224 cases including 148 male subjects and 76 female subjects aged from 30 to 87 years old were selected by cluster sampling from 5013 patients performing whole body 18F-FDG PET-CT scan in our hospital. They were scanned from top of the head to center of the thigh. BMD of the lumbar vertebrae 3, 4, and 5 were measured. The difference of L3-4, L4-5 BMD values and SUV values between different genders were analyzed. The relationship with IDD was also analyzed. Results BMD and SUV values of L3-4 and L4-5 had no statistical difference between genders. Nevertheless, the statistical difference was shown in 65-87 years old age group. BMD and SUV values were lower in old women than in old men. BMD in IDD group was less than that in non-IDD group (P<0.05). SUV in IDD group was higher than that in non-IDD group (P<0.05). BMD of L3-4 and L4-5 in different IDD grade was different. The higher the IDD grade was, the lower the BMD values were Conclusion IDD causes the decrease of BMD value and the increase of SUV. |
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