| Objective To analysis the correlation between bone mineral density (BMD) and the serum biochemical index in patients with type 2 diabetes (T2DM) and osteoporosis, in order to provide theoretical evidence for the prevention, diagnosis, and treatment of osteoporosis. Methods A total of 72 elderly patients with T2DM were randomly selected in our hospital. Fasting blood sample were collected to determine glycosylated hemoglobin, blood sugar, blood biochemical parameters, calcium, and phosphorus. BMD was determined using dual energy X-ray absorptiometry. According to the BMD value, the patients were divided into osteoporosis group and non-osteoporosis group. Gender, age, disease time course, BMI, FPG, TC, HDL, LDL, serum calcium and phosphorus, and HbA1c were compared between the 2 groups. The correlation study was conducted. Results According to the WHO criteria, in this study patients with osteoporosis were up to 44.4%. The age of patients in osteoporosis group was significantly lower, the course of disease was significantly longer, and the BMI was significantly lower than those in non-osteoporosis group. FPG, HbA1c, serum calcium and phosphorus, and HDL were not statistically different between the 2 groups. TC and LDL in osteoporosis group were higher than those in non-osteoporosis group. Correlation analysis indicated that BMD was positively correlated with BMI and calcium, but negatively correlated with age, course of disease, TC, and LDL. Phosphorus, FPG, HbA1c, and HDL were not correlated with BMD. In addition, BMD of older women was significantly lower than that of older men. Conclusion Age is the important risk factor of osteoporosis, but higher BMI is a protective factor in T2DM patients. We should pay attention to the effect of metabolic disorder of lipid and glucose on bone mineral density. Old women should pay more attention to the risk of osteoporosis. |