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| 抗精神病药物对患者骨质状况影响的回顾性队列研究 |
| A retrospective cohort study of the effect of antipsychotic drugs on the bone status |
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| DOI：10.3969/j.issn.1006-7108.2017.01.019 |
| 中文关键词: 抗精神病药物 血清Ⅰ型前胶原氨基酸前肽（PINP） 骨钙素（BGP） |
| 英文关键词:Antipsychotic drug Amino terminal propertied of type I precollege (PINP) Bone glaprotein (BGP) |
| 基金项目:昆山市科技计划项目（项目编号： KS1332） |
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| 中文摘要: |
| 目的 探究抗精神病药对患者骨质状态的影响，为骨质疏松的预防提供相应的对策与措施。方法 本研究采用回顾性的队列研究，通过纳入抗精神病用药组（暴露组）和非用药组（对照组），回顾性的收集患者既往用药情况及两组的基础信息，并进行血清?型前胶原氨基酸前肽 (PINP)、骨钙素（BGP）及骨密度（桡骨远端）的检测。采用协方差分析抗精神病药物对患者骨质状况的影响。结果 抗精神病药物会在一定程度上影响患者的骨质状况，协方差分析结果显示，调整了年龄、牛肉及牛奶的食用频数等3个指标后，暴露组的骨钙素（BGP）、血清Ⅰ型前胶原氨基酸前肽（PINP）的水平均低于对照组。结论 抗精神病药物对患者骨质状态有一定的影响，建议该类人群提早采取措施预防骨质疏松。 |
| 英文摘要: |
| Objective To exploring the effect of antipsychotic drugs on bone status, in order to provide corresponding strategy for the prevention of osteoporosis. Methods A retrospective cohort study was conducted. The medication situation and basic information of the patients in antipsychotic medication group (exposed group) and the control group were collected. Amino terminal propertied of type I precollege (PINP), bone glaprotein (BGP), and bone mineral density of the distal radius of the subjects were detected. The covariance analysis was used to analyze the effect of antipsychotic drugs on the bone status. Results Antipsychotic drugs affected the bone status of the patients to a certain extend. The covariance analysis showed that the levels of BGP and PINP in the exposed group were lower than those in the control group after adjustment for age, beef and milk consumption frequency. Conclusions Antipsychotic drugs affect the bone status of the patients, suggesting that early measures should be taken to prevent from osteoporosis. |
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