| Renin angiotensin system (RAS) includes Ang I, Ang II, and their receptors AT1R, AT2R, rennin, and ACE, et al. Ang II is the main active substances in RAS. They all express in the bone tissue, and play an important role in growth, development, and metabolism of the bone. Diabetic osteoporosis is a bone disease which is characterized by bone mass loss and microstructure damage of the bone. It is one of the most common complications of diabetes, with the highest disability rate. At present, the treatment of diabetic osteoporosis is based on the known pathogenesis, but from a long-term clinical experience, it has a lot of limitation, such as high price and more side effects, etc. Therefore, we need to further explore the mechanism of the occurrence and development diabetic osteoporosis, to look for potential therapeutic targets, and to break through in the prevention and treatment. This paper illustrates the role of RAS in diabetic osteoporosis from the aspect of biology. The paper also focuses on the effect of RAS on insulin resistance, insulin resistance on bone metabolism, RAS on bone metabolism, and RAS antagonists diabetic osteoporosis, which may contribute to future drug treatment. |