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| 血清Omentin-1水平与2型糖尿病并发骨质疏松症的相关性研究 |
| The correlation between serum Omentin-1 and osteoporosis in patients with type 2 diabetes |
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| DOI：10.3969/j.issn.1006.7108.2017.02.001 |
| 中文关键词: 网膜素-1 2型糖尿病；骨质疏松症 |
| 英文关键词:Omentin-1 Type 2 Diabetes Mellitus Osteoporosis |
| 基金项目:湖南省（南华大学)研究生科研创新项目（2016XCX54) |
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| 中文摘要: |
| 目的 探讨血清网膜素-l(Omentin-l)与2型糖尿病（T2DM)并发骨质疏松症的关系。方法 选取30例T2DM伴骨质疏松患者（T2DM +OP组），30例T2DM不伴骨质疏松患者（T2DM组），30例正常健康体检者（正常组）。酶联免疫吸附试验 (ELISA)法测定血清Omentin-l、RANKL、OPG、OCN、TRAP-5b水平，并测定空腹血糖（FPG)、糖化血红蛋白（HbAlc)、空腹胰岛素（FINS)等指标；BMD采用双能X线吸收骨密度仪扫描腰椎（L1-L4)检测。结果 ①血清Omentin-1水平在T2DM + OP组 (31.90 ±2.95) μg /L、T2DM 组（37. 85 ±4. 52) μg /L 均明显低于正常人组（39. 91 ±4. 24) μg /L, T2DM + OP 组较 T2DM 组明显降低（P<0.05)。②血清 Omentin-1 与OCN、OPG 呈正相关（P <0. 01)，与 FPG、HbAl c、FINS、胰岛素抵抗指数（HOMA-IR )、 RANKL及RANKL/OPG比值呈负相关（P < 0. 01)。③Omentin-1是2型糖尿病骨质疏松的保护因素，而HOMA-IR及TRAP-5b 为危险因素。结论 血清网膜素-1在2型糖尿病并发骨质疏松的过程中逐渐降低，且伴有RANKL/OPG、TRAP-5b的增高。 |
| 英文摘要: |
| Objective To investigate the correlation between serum Omentin-1 and osteoporosis ( OP) in patients with type 2 diabetes (T2DM). Methods 30 T2DM patients with osteoporosis were enrolled as the T2DM + OP group, 30 T2DM patients without osteoporosis as the T2DM group, and 30 healthy subjects were included in the control group. Enzyme-linked immuno sorbent assay (ELISA) was used to determine the levels of serum Omentin-1，osteocalcin(OCN)，RANKL, OPG and tartrate resistant acid phosphatase-5b (TRAP-5b). The serum levels of FBG, HbAlC，and FINS were also measured. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA) at the lumber spine (L1-L4). Results ①The serum Omentin-1 levels in T2DM with OP group [ (31. 90 ±2. 95) μg /L ] and T2DM group [ (37. 85 ±4. 52) μg /L] were significantly lower than that in the control group [ (39. 91 ±4. 24) μg /L] , and the serum Omentin-1 levels were significantly lower in the T2DM + OP group when compared with the T2DM group (P <0. 05).② The Pearson’ s correlation analysis demonstrated that serum Omentin-1 levels were negatively correlated with FPG, HbAlc, FINS, HOMA-IR, RANKL and RANKL/OPG ratio (P <0. 01) , but positively correlated with OPG and OCN ( P<0. 01).③Logistic Regression indicated that Omentin-1 was an protective factor for DOP, while HOMA- IR and TRAP-5 b were risk factors for DOP. Conclusion With the progression of osteoporosis in T2DM patients, serum Omentin- 1 levels decrease gradually, while TRAP-5b and RANKL/OPG ratio increase. |
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