| Objective To investigate the levels of bone mineral density and bone biomarkers in postmenopausal women with type 2 diabetes mellitus. Methods In total 128 cases of postmenopausal women presented to the 309 Hospital Bone Medical Department between December 2014 to March 2016 were studied, including 60 patients with type 2 diabetes, age 50-69 ( average 60. 8) years, and 68 cases without diabetes, aged 50-69 (average 59.8) years. All were measured for lumbar L2-L4 and left hip bone mineral density using a HOLOGIC dual-energy bone densitometer. Other measures include patients’ height，weight, body mass index (BMI)，records on admission, biochemical measures of blood lipids, blood calcium, phosphorus, magnesium, fasting glucose, and enzyme-linked immunosorbent determination of B-ALP, CTX, PINP and 25 hydroxy vitamin D levels. Comparisons were made between the two groups on bone mineral density and bone biomarkers. Results Between the two groups, there were no significant differences in age, height, weight, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood magnesium and blood lipid levels. Hip and lumbar spine bone mineral density, and 25 hydroxy vitamin D and PTH levels between the two groups were also not significantly different. Fasting blood glucose, blood calcium levels and bone metabolic markers CTX of the observation group was higher, and OC and ALP levels were lower than the control group, the differences were statistically significant. Conclusion Bone turnover markers in postmenopausal women with type 2 diabetes were abnormal，and could be a predictor of diabetic osteoporosis. |