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| 老年男性2型糖尿病患者骨密度与炎症因子相关性研究 |
| Correlation between bone mineral density and inflammatory cytokines in elderly male diabetic patients |
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| DOI：10.3969/j.issn.1006.7108.2017.02.016 |
| 中文关键词: 2型糖尿病 骨密度 骨质疏松 炎症因子 老年 |
| 英文关键词:Type 2 diabetes Bone mineral density Osteoporosis Inflammatory cytokines Elderly |
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| 中文摘要: |
| 目的 探讨老年男性2型糖尿病患者骨密度与炎症因子的相关性。方法 选取我院老年病科住院的280例老年男性2型糖尿病患者，计算体重指数（BMI),测定空腹血糖（FBG)、糖化血红蛋白（HBAlc)、C反应蛋白（CRP)、单核细胞趋化因子 (MCP-1)、肿瘤坏死因子（TNF-α)、白细胞介素6(IL-6)及骨密度参数（T值和Z值），分析骨密度与炎症因子的相关性。结果 糖尿病患者随着骨密度降低，年龄增加（F = 8.928，P<0.01)、HBAlc增加（F = 7.290，P<0.01),炎症因子CRP、TNF-α及IL- 6 均增高（F分别为 6. 928,8. 301,4. 290,均 P<0. 05) ;BMD 与年龄、CRP、TNF-α、IL-6 呈负相关(r值分别为-0. 229、-0. 079、 -0.090、-0. 089,均P<0. 05)，与BMI呈正相关（r = 0. 088,P<0. 05)，通过Logistic回归分析校正混杂因素后显示，年龄为骨质疏松的独立危险因素（OR值分别为1. 07,P <0. 05)。结论 老年男性2型糖尿病患者骨密度与炎症因子存在相关性，炎症因子在DOP的发生发展过程中起到重要作用，但并非其独立危险因素。 |
| 英文摘要: |
| Objective To evaluate the relationship between bone mineral density and inflammatory cytokines in elderly male patients with type 2 diabetes. Methods In total 280 elderly male patients with type 2 diabetes were selected for health examination. Body mass index ( BMI) were calculated. Levels of FBG, HBAlc, CRP, MCP-1, TNF-α, IL-6 and Bone mineral density parameters (T and Z) were assessed. The correlations of BMD with inflammatory cytokines were analyzed. Results In patients with type 2 diabetes, with the decrease of BMD, age, HBAlc CRP, TNF-α, IL-6 were increased( F = 8. 928, 7.290，6.928， 8. 301, 4. 290, all P< 0，01). Spearman analysis showed that BMD was negatively correlated with age, CRP，TNF-α and IL-6( r= -0. 229，- 0.079, - 0.090，- 0.089，all P < 0. 05) , and was positively correlated with BMI( r = 0. 088 ,P <0. 05). Age was an independent risk factor for diabetic osteoporosis (DOP) (OR = 1. 07, P < 0. 05). Conclusions The present study demonstrated a relationship between BMD and inflammatory cytokines in elderly patients with type 2 diabetes. The inflammatory cytokines had important effect on the development of DOP, but were not independent risk factors. |
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