| The relationship between osteoarthritis and osteoporosis has been studied for about half a century. However, the relevance of the two diseases is still controversial. Osteoarthritis and osteoporosis as two diseases related to bone metabolism, both are influenced by a number of factors such as estrogen, NO, genetic factors, PTH, etc. Both diseases are degenerative diseases related to human ageing but the pathogenesis is different. Some believe the two diseases are opposite, as OA patients in general have high BMD. However, longitudinal studies have shown that OA patients had higher BMD but increased fracture risk. Some research showed that increased BMD might slow the progression of OA. Some researchers think that there is no relevance between the two. In this review, by reviewing nearly 10 years national and international literature, we explored the exact relationship between the two diseases, with the aim to guide the application in clinical work, and to benefit patients in practice. |