| The latest experimental research progress in the treatment of osteoporosis with aspirin is reviewed. The characteristics of aspirin, its application in clinic, and the mechanism of aspirin acting in the treatment of osteoporosis are introduced, in order to provide a new method for osteoporosis treatment. On the basis of experiments in vivo and in vitro, with sub-classified as the laboratory test indexes，national and international literatures on treatment of postmenopausal osteoporosis with aspirin in recent years are extensively reviewed and analyzed. The bone mineral density, bone histomorphometry, bone biomechanics, and bone metabolism are summarized, respectively, from in vivo experiments. From in vitro experiments, experimental research progress of aspirin in the treatment of postmenopausal osteoporosis related mechanism of signaling pathways, cytokines，and related gene expression is summarized. Based on these, the problems of current research are pointed out. The problems mainly include the unknown mechanism of aspirin in the tre^jment of postmenopausal osteoporosis, and a lack of relevant epidemiological studies. At last, the research ideas of next step are proposed, in order to offer the reference for related researchers. |