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| 肿瘤坏死因子受体相关因子6与骨代谢的研究进展 |
| Advances in tumor necrosis factor receptor-associated factor 6 and bone metabolism |
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| DOI：10.3969/j.issn.1006.7108.2017.02.028 |
| 中文关键词: 肿瘤坏死因子受体相关因子6 破骨细胞 成骨细胞 骨质疏松 |
| 英文关键词:Tumor necrosis factor receptor-associated factor 6 Osteoclast Osteoblast Osteoporosis |
| 基金项目:国家自然科学基金青年科学基金项目（81303124) |
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| 中文摘要: |
| TRAF6是肿瘤坏死因子受体相关因子家族（TRAFs)中既可与肿瘤坏死因子受体（TNFR)超家族结合，又可与白细胞介素-1受体/Toll样受体（IL-1R/TLR)超家族相互作用来传递细胞外信号的一种细胞内接头蛋白，在炎症反应、免疫应答、骨代谢中发挥着重要作用。本文现就TRAF6在骨代谢中的研究进展作一综述。 |
| 英文摘要: |
| TRAF6 is a member of TRAF family, which serves as an adapter coupling for the TNF receptor (TNFR) superfamily in intracellular signaling events. Moreover, TRAF6 is unique for signaling downstream of another receptor family, the interleukin-1 (IL-1) receptor/Toll-like receptor (IL-1R/ TLR) superfamily, which plays critical roles in inflammation and innate and adaptive immune responses. TRAF6 regulates inflammation and links immunity to bone metabolism. This paper reviews the current studies in TRAF6 on bone metabolism. |
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