| Spondyloarthritis (SpA) is a family of chronic inflammatory rheumatic disease. Clinical features of this group include inflammatory back pain，asymmetrical peripheral oligoarthritis, enthesitis, and specific organ involvement such as anterior uveitis, psoriasis, and chronic inflammatory bowel disease. Osteoporosis or osteopenia is common in SpA, and is the most frequent complication. Currently, bone mineral density is evaluated mostly by using quantitative computed tomography (QCT) , quantitative ultrasound, or dual-energy X-ray absorptiometry (DXA). The prevalence varies according to the detection site. QCT is the most accurate measurement, while DXA at lateral spine and femoral neck is more available in China. Osteoporosis is more common in ankylosing spondylitis than in psoriatic arthritis. The prevalence of osteoporosis may increase with the course of disease. In addition to bisphosphonate, TNF-α inhibitors have certain effect on osteoporosis secondary to SpA. |