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| MicroRNA在强直性脊柱炎成骨、破骨机制中的作用 |
| The role of microRNA in the mechanism of bone formation and resorption in ankylosing spondylitis |
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| DOI：10.3969/j.issn.1006.7108.2017.03.024 |
| 中文关键词: 强直性脊柱炎 微小RNA 成骨细胞 破骨细胞 |
| 英文关键词:Ankylosing spondylitis Micro RNA Osteoblast Osteoclast |
| 基金项目:国家自然科学基金青年项目（81403378);中日友好医院青年科技英才培养计划（2014-QNYC-B-02) |
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| 中文摘要: |
| 炎性骨破坏和新骨形成是强直性脊柱炎（ankylosing spondylitis, AS)的典型病理改变，AS早期以炎症为主，晚期出现异位骨化和骨破坏，异位骨化和骨破坏两种矛盾的表现反映了强直性脊柱炎患者成骨与破骨过程之间的动态平衡被打破。其发病机制尚不完全清楚，目前研究认为，AS复杂的新骨形成机制与Wnt/β-catenin信号通路及BMP/Smads通路密切相关，而破骨细胞则在骨破坏过程中起重要作用，RANKL/RANK/OPG系统中的细胞因子是调控破骨细胞分化成熟的关键因子。Micro RNA可调节成骨细胞、软骨细胞和破骨细胞的分化与功能，是骨形成、骨吸收、骨重塑和修复过程中的关键调节因子。研究MicroRNA在强直性脊柱炎成骨、破骨机制中的作用，可为AS的诊断和治疗提供新的依据。 |
| 英文摘要: |
| Inflammatory bone destruction and new bone formation are typical pathological changes of ankylosing spondylitis (AS). AS is characterized by inflammation in the early stage, but by both bone destruction and heterotopic ossification in the later period. The paradoxical expression of heterotopic ossification and bone destruction reflects that the dynamic balance between bone formation and resorption process in AS patients is broken. The pathogenesis of AS is not fully discovered. Present studies suggest that the complex new bone formation mechanism of AS is closely related to the Wnt/β-catenin signaling pathway and BMP/Smads pathway. Osteoclasts play an important role in the process of bone destruction. The cytokines in the RANKL/OPG/RANK system are the key factors in regulating the mature and differentiation of osteoclasts. MicroRNA can regulate the differentiation and function of osteoblasts, chondrocytes, and osteoclasts, which is the key regulatory factor in the process of bone formation and resorption, restoration, and repair. Studying the role of microRNA in bone formation and resorption of AS provides new evidence for the diagnosis and treatment of AS. |
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