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| 中药熏洗联合西药治疗寒湿痹阻型膝骨关节炎的临床观察 |
| Clinical observation on fumigating Chinese herbal medicine combined with western medicine in treating knee osteoarthritis due to cold and damp block |
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| DOI：10.3969/j.issn.1006.7108.2017.04.019 |
| 中文关键词: 中医中药 膝骨关节炎 中药熏洗 联合用药 |
| 英文关键词:Chinese Traditional Medicine Knee osteoarthritis Traditional Chinese medicine fumigation Medication in combination |
| 基金项目:甘肃省自然科学研究基金项目（1212RJZA087) |
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| 中文摘要: |
| 目的 探讨中药熏洗治疗膝骨关节炎的临床疗效及安全性。方法 将60例膝骨关节炎患者随机分为治疗组和对照组各30例。两组均给予盐酸氨基葡萄糖胶囊口服,每次0.75 g，每日2次。对照组加用萘普生缓释胶囊口服，每次0.5 g，每日1 次。治疗组加用健步通络熏洗方熏洗治疗，每日1次，每周熏洗5次，两组均治疗6周。观察两组患者治疗前后膝关节疼痛程度、肿胀程度、关节功能评分、血清肿瘤坏死因子（TNF-α)、白细胞介素-l(IL-1)、转化生长因子-β(TGF-β)水平变化情况，并评价临床疗效。结果 治疗组总有效率93. 3% ;对照组总有效率90.0%，两组总有效率比较差异无统计学意义（P> 0.05);两组均可明显缓解关节疼痛、肿胀,改善关节功能，两组比较差异无统计学意义（P>0. 05);治疗组血清中TNF-α、IL-1较对照组下降，两组比较差异有统计学意义（P <0.05)，治疗组血清中TGF-β较对照组上升，差异有统计学意义（P<0. 05)。结论 健步通络熏洗方熏洗治疗膝骨关节炎疗效与萘普生缓释胶囊相当，安全性良好，值得临床推广应用。 |
| 英文摘要: |
| Objective To explore the clinical effect and safety of traditional Chinese medicine fumigation in the treatment of knee osteoarthritis. Methods 60 cases of knee osteoarthritis were randomly divided into treatment group and control group with 30 cases in each group. Both groups were given glucosamine hydrochloride capsule orally, each 0. 75g, twice daily. The control group also received oral naproxen sustained-release capsule, each 0. 5g, once daily. Treatment group also received Jianbutonglu fumigation treatment, once daily, 5 times a week. Both groups received treatments for 6 weeks. The levels and changes of serum tumor necrosis factor (TNF-α), interleukin-1 (IL-1 ) and transforming growth factor-β ( TGF-β) were observed before and after the treatment. The clinical effects were evaluated and the changes in pain, swelling and joint function were recorded. Results The total effective rate was 93. 3% in the treatment group and 90. 0% in the control group. There was no significant difference in the total effective rate between the two groups (P > 0. 05). There was no significant difference between the two groups in pain， swelling and joint function (P > 0. 05). The levels of serum TNF-α and IL-1 in the treatment group were lower than those in the control group ( P <0.05). The serum level of TGF-β in the treatment group was higher than that in the control group, the difference was significant ( P < 0. 05). Conclusion Jianbu Tongluoxunfang fumigation has the same efficacy as naproxen sustained-release capsule for the treatment of knee osteoarthritis, is quite safe and worthy of clinical application. |
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