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| 非创伤性股骨头坏死相关信号通路研究进展 |
| Research progress on the signal pathway of non-traumatic osteonecrosis of femoral head |
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| DOI：10.3969/j.issn.1006.7108.2017.04.028 |
| 中文关键词: 非创伤性股骨头坏死 信号通路 Wnt/β-catenin |
| 英文关键词:NONFH Signal pathway Wnt/β-catenin |
| 基金项目:国家自然科学基金项目（项目编号：81473712/ H2710);甘肃省卫生行业计划项目（项目编号：GSWSKY-2015-13) |
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| 中文摘要: |
| 非创伤性股骨头坏死（NONFH)是目前被国内外均列为尚未解决的难治性疾病之一，目前发现主要的致病原因有酒精、激素、吸烟和遗传因素等，但是对于各因素的具体发病机制仍尚不清楚。研究发现多种信号通路与人体代谢性疾病的发病具有相关性，骨代谢性疾病的研究中亦发现多种信号通路在NONFH的发病中具有一定的调控作用，如Wnt/β-catenin、OPG/ RANKL/RANK、TLR4、HIF-lα、RhoA/ROCK和MAPK等信号通路在NONFH的发生和发展中具有抑制破骨细胞的分化、促进成骨细胞的分化、改善股骨头部的血液供应等作用，因此本文就NONFH相关的信号通路做一综述，旨在为NONFH的预防和治疗找到新的方法和途径。 |
| 英文摘要: |
| Non-traumatic osteonecrosis of the femoral head (NONFH) is classified as unresolved refractory disease internationally. The main causes currently found include alcohol，hormones，smoking and genetic factors，but the specific mechanism of each factor is still unclear. Research has found that there is a relationship between multiple signaling pathways and the incidence of human metabolic diseases. Research on bone metabolic diseases also found that various signaling pathways play a role in the pathogenesis of NONFH, such as Wnt/β-catenin, OPG/RANKL/RANK, TLR4, HIF-1，RhoA/ROCK alpha and MAPK signal pathway involve in the occurrence and development of NONFH through inhibiting osteoclast differentiation, promoting osteoblast differentiation, improving the blood supply of the femoral head and so on. This article reviewed NONFH related signal pathways, with the aim of finding new methods and approaches for the prevention and treatment of NONFH. |
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