| Objective To evaluate the preventive effect of Chinese herbal compound of tonifying kidney and strengthening spleen on prevention of the refracture after percutaneous vertebroplasty for osteoporotic vertebral fractures. Methods Ninety-two patients with osteoporotic vertebral fractures, who underwent percutaneous vertebroplasty or percutaneous kyphoplasty, were randomly divided into observation group and control group, with 46 cases in each group. All patients were followed up for 12 months. Bone mineral density (BMD) and the status of vertebral fracture were recorded at the time of discharge, 3 months after surgery, and at the last follow-up. The patients were recorded with Oswestry dysfunction index. Results Eighty-five patients were finally enrolled in the study, including 43 cases in the observation group and 42 cases in the control group. BMD of the lumbar spine and hip increased in observation group, but decreased in control group. There was significant difference in BMD of the lumbar spine and hip at the last follow-up (P<0.05) in control group. At 3 months after surgery, there was significant difference in hip BMD between observation group and control group (P<0.05). The difference of BMD in the lumbar spine and hip was statistically significant between observation group and control group at the last follow-up (P<0.05). At the last follow-up, there were 2 cases of fracture in the observation group and 8 cases in the control, and the difference was statistically significant (P<0.05). In the aspect of functional improvement, the observation group was better than the control group after 3 months and at the final follow-up, and the difference was statistically significant (P<0.05). Conclusion Chinese herbal compound of tonifying kidney and strengthening spleen improves BMD, effectively maintains the change of BMD, reduces the risk of vertebral refracture, and obviously improves the function of patients after operation. |