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| 在有氧运动的基础上服用补肾壮骨颗粒对改善去势大鼠骨质疏松症病情的协同效果 |
| The synergistic effect of aerobic exercise combined with the nourishing kidney and strengthening bone granule on rats with emasculation-induced osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2017.06.007 |
| 中文关键词: 补肾壮骨颗粒 有氧运动 绝经后骨质疏松症 协同效果 |
| 英文关键词:Nourishing kidney and strengthening bone granule Aerobic exercise Postmenopausal osteoporosis Synergistic effect |
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| 中文摘要: |
| 目的 探讨有氧运动与补肾壮骨颗粒综合疗法治疗绝经后骨质疏松症（postmenopausal osteoporosis, PMOP)的疗效及机理，为有效防治PMOP提供理论依据。方法 采用去势大鼠模型，分为假手术组(n = 10)、模型组(n=10)、阳性组(n=10)、有氧运动组(n=10)、补肾壮骨颗粒组(n=10)和联合组（n = 10),去势后2 w运用有氧运动、补肾壮骨颗粒以及二者联合等干预方法防治大鼠发生的骨质疏松。连续12 w检测各组大鼠骨组织生物力学，同时采用实时荧光定量PCR技术检测骨代谢相关指标表达。结果 与假手术组相比，模型组大鼠的左股骨最大负荷、左胫骨最大负荷和第四腰椎结构强度均显著降低(P<0.05)。与模型组相比，阳性组、有氧运动组、补肾壮骨颗粒组和联合组的左股骨最大负荷、左胫骨最大负荷和第四腰椎结构强度均显著提高（P <0.05)。荧光定量PCR结果显示，与模型组相比，阳性组、有氧运动组、补肾壮骨颗粒组和联合组的RANKL和OPG均显著提高（P <0.05)，而RANKL/OPG显著降低（P <0.05)。与阳性组相比，联合干预组的RANKL和OPG均显著提高（P <0.05)，而RANKL/OPG显著降低（P<0.05)。结论 补肾壮骨颗粒和运动的综合性治疗策略能通过降低骨组织中OPG/ RANKL比值，进而抑制破骨细胞的活性来改善去势大鼠骨质疏松症病情，其疗效要优于单纯运动及补肾壮骨颗粒。 |
| 英文摘要: |
| Objective To determine the efficacy and the mechanism of aerobic exercise combined with the nourishing kidney and strengthening bone granule for the treatment of postmenopausal osteoporosis (PMOP) , in order to provide a theoretical basis for improving the prevention and treatment of PMOP. Methods A total of 60 female rats were randomly divided into sham operation group, model group, positive control group, nourishing kidney and strengthening bone granule group，exercise group, and combined treatment group. Each group contained 10 rats. The duration of drug administration was 12 weeks. The changes of bone histomorphometry of rats in different groups were observed. The expression of bone metabolism-related protein was detected using real-time PCR. Results Compared with the sham group, the maximal loading of the left femur, the left tibia, and the structure strength of the fourth lumbar vertebra in the model group significantly decreased (P <0. 05). Compared with the model group, the maximal loading of the left femur, the left tibia, and the structure strength of the fourth lumbar vertebra in the positive group, the aerobic exercise group, the nourishing kidney and strengthening bone granule group, and the combination group significantly increased (P <0. 05). Compared with the model group, RANKL and OPG in the positive group, the aerobic exercise group, the nourishing kidney and strengthening bone granule group, and the combination group significantly increased (P < 0. 05) , while the RANKL/OPG significantly decreased ( P<0.05). Compared with the positive group, RANKL and OPG in the combined intervention group significantly increased (P<0.05), and RANKL/OPG significantly decreased ( P < 0. 05 ). Concluison The combination of physical exercise and the nourishing kidney and strengthening bone granule is more effective for the treatment of postmenopausal osteoporosis than exercise or the use of nourishing kidney and strengthening bone granule alone. The mechanism is through the decrease of OPG/RANKL, resulting in the inhibition of osteoclast activity. |
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