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| 女性年龄相关的股骨颈几何参数参考值 |
| Age-related reference value of the femoral neck geometric parameters in females |
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| DOI：10.3969/j.issn.1006.7108.2017.06.010 |
| 中文关键词: 女性人群 骨密度 股骨颈几何参数 参考数据库 |
| 英文关键词:Female population Bone mineral density Femoral neck geometric parameters Reference database |
| 基金项目:国家自然科学基金项目（81500685) |
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| 中文摘要: |
| 目的 调查女性人群年龄相关的股骨颈几何参数（FNGPs)和建立FNGPs参考数据库。方法 女性健康志愿者5478名 (年龄10?91岁），采用DXA骨密度仪测量受试者FNGPs，包括股骨颈外周直径（OD)、横截面积（CSA)、皮质厚度（CT)、内皮质直径（ED)、抗曲比率（BR)、截面系数（SM)、截面转动惯量（CSMI)和抗压强度指数（CSI),并分析其随年龄的变化关系。结果 各种FNGPs随年龄的分布趋势均采用三次回归模型拟合优度最佳，拟合曲线方程的决定系数均有显著性意义（R2 = 0.047~0.344，均P =0.000)，但它们的散点分布趋势随指标而不同，其中CSA、CT、SM、CSMI和CSI在35岁之前随年龄而增加，之后随年龄增加而逐渐下降；只有BR约在40岁之后则随年龄而快速增加。调整年龄之后，身高、体重和BMI与股骨颈 OD、CSA、CT、ED、SM和CSMI呈显著正相关关系（r=0. 043?0. 546，均P = 0. 002?0.000)，BR和CSI则与身高、体重和BMI 呈负相关关系（r= -0.057至-0.387，均P = 0.000)。结论 本研究建立的女性人群FNGPs参考数据库，将为临床评价和预测女性股骨颈骨质疏松性骨折风险提供可靠的参考值。 |
| 英文摘要: |
| Objective To evaluate the age-related femoral neck geometric parameters (FNGPs) in women and establish the reference database of FNGPs. Methods This study included 5478 healthy females (aged from 10 to 91 years old). DXA fan- beam bone densitometer was used to measure FNGPs，including the outer diameter ( OD)，cross-sectional area ( CSA)，cortical thickness (CT)，endocortical diameter (ED), buckling ratio (BR) , section modulus (SM)，cross-sectional moment of inertia (CSMI) , and compression strength index (CSI). The relationship between the changes of above parameters and the age was analyzed. Results The age-related trends of FNGPs were fitted with the best goodness-of-fit by applying the cubic regression model，and the determination coefficients of fitting curve equation were significant (R2 =0.047 -0. 344，P =0.000). However, their scatter distribution trend varied according to the index. CSA, CT, SM, CSMI, and CSI increased with age before 35 years old, then decreased with age. Only BR rapidly increased with age after about 40 years old. After adjustment of age，the height, weight，and body mass index (BMI) were significantly positively correlated with OD, CSA, CT, ED, SM, and CSMI of the femoral neck (r = 0. 043 -0. 546，P=0. 002 - 0. 000). BR and CSI were negatively correlated with the weight and BMI ( r =- 0. 057 to - 0. 387, P = 0. 000). Conclusion The establishment of female FNGPs reference database in our study provides reliable reference value for clinical evaluation and prediction of the risk of the femoral neck osteoporotic fracture in women. |
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