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| 不同剂量骨化三醇治疗绝经后骨质疏松疗效对比 |
| Comparison of the effects of different doses of calcitriol on the treatment of postmenopausal osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2017.06.013 |
| 中文关键词: 骨化三醇 绝经后骨质疏松 阿仑膦酸钠 疗效 |
| 英文关键词:Calcitriol Postmenopausal osteoporosis Alendronate sodium Effects |
| 基金项目:四川省科技支撑计划（2010FZ0061);四川省科技支撑计划(2013FZ0051);四川省杰出青年培养计划（2012JQ0050) |
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| 中文摘要: |
| 目的 对比不同剂量骨化三醇治疗绝经后骨质疏松的临床疗效。方法 将我院门诊治疗的786例绝经后骨质疏松患者随机分为两组，每组393例。一组给予骨化三醇0.25μg (骨化三醇0.25μg治疗组），每日一次;另一组给予骨化三醇0. 50μg（骨化三醇0. 50μg治疗组），每日一次。两组患者都给予钙尔奇D 2粒（每粒含离子钙600 mg和活性维生素D 3. 125μg)， 阿仑膦酸钠70 mg每周一次，连续治疗一年。测量、评价并统计两组患者治疗前后和两组患者治疗后腰椎正位（L2-4和左右股骨颈骨密度（Bone Mineral Density, BMD)和腰背疼痛程度。结果 治疗一年后两组患者腰椎和股骨颈BMD均显著增加（P <0. 05) ；冶疗后，骨化三醇0. 50μg治疗组腰椎和股骨颈BMD显著高于骨化三醇0. 25μg治疗组；疼痛程度显著低于骨化三 醇0.25μg治疗组（P<0.05)。结论 绝经后骨质疏松的三联疗法（钙、活性维生素D、双膦酸盐），骨化三醇0.25μg剂量不足，0.5μg能显著提高临床疗效。 |
| 英文摘要: |
| Objective The aim of this study was to compare the effects of different doses of calcitriol on the treatment of postmenopausal osteoporosis. Methods 786 cases of postmenopausal osteoporosis were randomly divided into two groups, with 393 cases in each group. One group received 0.25μg Calcitriol (0. 25μg Calcitriol group) once per day for one year, and the other group received 0. 50μg Calcitriol (0. 50μg Calcitriol group) once per day for one year. During the study period, both groups received 70 mg of Alendronate Sodium once weekly and two Caltrate tablets per day ( each tablet contains 600 mg of calcium and 0. 125μg cholecalciferol). Bone mineral density (BMD) of lumber spine (L2-4) and femoral neck of the two groups of patients before and after treatment were measured. Result One year after the treatment, in both groups BMD of lumbar spine and femoral neck increased significantly and pain reduced significantly (P < 0.05). Compared with the 0. 25μg Calcitriol group, the increase of lumbar spine and femoral neck BMD in the 0. 50μg Calcitriol group after treatment was significantly higher (P < 0. 05), and the degree of pain was significantly lower (P <0. 05). Conclusion In the triple therapy (Calcium, active vitamin D, bisphosphonates) of postmenopausal osteoporosis, Calcitriol 0. 25μg was an inadequate dose, and 0. 50μg Calcitriol was more effective. |
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