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| 骨疏康胶囊治疗糖皮质激素性骨质疏松症的临床研究 |
| Clinical study on the effects of gushukang capsules in treating glucocorticoid induced osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2017.06.020 |
| 中文关键词: 骨疏康胶囊 糖皮质激素性骨质疏松症 骨密度 骨钙素 血清钙 骨特异性碱性磷酸酶 25-羟维生素D I型前胶原N 端前肽 |
| 英文关键词:Gushukang capsules Glucocorticoid induced osteoporosis Bone mineral density Osteocalcin Serum calcium Bone alkaline phosphatase 25- hydroxyvitamin D N-terminal propeptide of type 1 precollagen |
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| 中文摘要: |
| 目的 观察骨疏康胶囊治疗糖皮质激素性骨质疏松症的疗效。方法 选取宁夏医科大学总医院门诊及住院确诊的风湿性疾病并糖皮质激素性骨质疏松症患者80例，随机分为试验组和对照组，每组各40例。试验组患者口服骨疏康胶囊4粒 BID，阿法骨化醇软胶囊0.5μg QD,碳酸钙D3片1片BID,对照组患者口服阿法骨化醇软胶囊0.5μg QD,碳酸钙D3片1片 BID,两组均连续用药12个月，观察其骨密度及骨代谢指标的变化。结果 试验组腰椎（L1-4)、股骨颈、大转子、全髋的骨密度均较对照组升高，与治疗前相比明显升高，差异均具有统计学意义（P <0.05)。骨代谢指标中，试验组血清钙治疗前后无明显变化（P >0.05)，骨钙素、碱性磷酸酶降低，25-羟维生素D、I型前胶原N端前肽升高，差异均有统计学意义（P < 0.05)。与对照组比较，血清钙与骨钙素无明显变化（P>0. 05),碱性磷酸酶降低,25-羟维生素D、I型前胶原N端前肽升高，差异均具有统计学意义（P <0. 05)。结论 骨疏康胶囊可改善糖皮质激素性骨质疏松症患者的骨密度和骨代谢，具有临床使用价值。 |
| 英文摘要: |
| Objective To evaluate the curative effect of Gushukang Capsules in the treatment of glucocorticoid induced osteoporosis. Methods Patients(80 cases) with rheumatic diseases and glucocorticoid induced osteoporosis attending the General Hospital of Ningxia Medical University were randomly divided into experimental and control groups, with 40 cases in each group. Patients in the experimental group were po administered with Gushukang Capsules 4 capsules BID, Alfacalcidol Soft Capsules 0. 5μg QD and Calcium carbonate D3 tablets 1 tablet BID, and patients in the control group were po administered with Alfacalcidol Soft Capsules 0. 5μg QD and Calcium carbonate D3 tablets 1 tablet BID. Patients in both groups were treated continuously for 12 months. After treatment, the changes of BMD and bone metabolism indexes in the two groups were studied. Results After treatment, BMD of L1-4, femoral neck, greater trochanter and total hip in the experimental group increased significantly compared with pre-treatment, and the increase was greater than the control group, both differences were statistically significant (P < 0. 05). For bone metabolism indexes, compared with pre-treatment, in the experimental group there was no significant change in serum calcium(P>0.05)，osteocalcin and alkaline phosphatase decreased significantly, and 25- hydroxyvitamin D and N-terminal propeptide of type 1 precollagen increased significantly (P < 0. 05). Compared with the control group，there were no significant differences in changes in serum calcium and osteocalcin, but alkaline phosphatase decreased significantly, and 25-hydroxy vitamin D and N-terminal propeptide of type 1 precollagen increased significantly (P < 0. 05) in the experimental group. Conclusion Gushukang Capsules can improve bone mineral density and bone metabolism in patients with glucocorticoid I nduced osteoporosis, thus has value in clinical application. |
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