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| 骨质疏松症患者骨密度与血清25羟维生素D的相关性研究 |
| The study of the relationship between BMD and the serum level of 25-OH vitamin D in patients with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2017.07.003 |
| 中文关键词: 血清25羟维生素D 骨密度；骨质疏松 |
| 英文关键词:25-(OH)D Bone mineral density Osteoporosis |
| 基金项目:中央军委后勤保障部卫生局保健专项课题（16BJZ57，13BJZ13) |
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| 中文摘要: |
| 目的 分析骨质疏松症患者骨密度与血清25羟维生素D的相关性。方法 记录397例50?97岁患者的年龄，检测腰椎1?4、左侧股骨颈、左侧股骨上端的骨密度（bone mineral density, BMD )，检测骨质疏松4项[甲状旁腺素（parathyroid hormone, PTH )、总 I 型胶原氨基端前肽（procollagen type 1 amino-terminal propeptide，PI NP )、β 胶原降解产物（beta collagen degradation products，β-CTX)、N 端骨钙素（N end of osteocalcin,N-MID)]及血清 25 羟维生素 D[25-(OH)D]的水平，根据 BMD 水平将受试者分为骨量正常组(n = 118)、骨量低下组(n = 153)和骨质疏松组(n = 126)。结果(1)骨量低下组及骨质疏松组的BMD均明显低于正常骨量组（P< 0.01)，骨质疏松组又明显低于骨量低下组（P <0. 01) ; (2)骨质疏松组25-(OH)D、 PTH、PlNP、β-Crosslaps及N-CTX均明显低于正常骨量组（P<0.01);(3)25-(OH)D与腰椎1?4、左侧股骨颈、左侧股骨上端 的BMD、PTH、PlNP、β-CTX无相关性（P >0.05),25-(OH)D与N-MID的相关系数为0. 193 (P < 0. 01)。不同骨密度组间的 25-(OH)D差异无统计学意义（P >0.05)。结论 老年人群普遍存在维生素D(vitamin D，VD)水平不足的现象，而骨质疏松症患者更为突出，其中VD严重缺乏和缺乏所占比例较大，为骨质疏松症的防治提供一定的数据参考，应注意加强宣教及防治。尚未发现25-(OH)D与骨密度之间存在着直接相关关系。 |
| 英文摘要: |
| Objective To investigate the relationship between BMD and the serum level of 25-OH vitamin D in patients with osteoporosis. Methods A total of 397 participators were enrolled. BMD of the lumbar 1-4，the left femoral neck, and the left proximal femur was measured. Parathyroid hormone ( PTH)，total collagen type I N-terminal propeptide (P1NP) , β collagen degradation products β-CTX, N end of osteocalcin (N-MID), and the level of serum 25 hydroxy vitamin D (25-OHD) were examined. They were divided into 3 groups according to their BMD levels： no osteoporosis group (n = 118)，osteopenia group (n= 153) , and osteoporosis group ( n= 126). Results (1) BMD in the osteopenia group and osteoporosis group was significantly lower than that in the normal bone mass group (P <0. 01)，and it was significantly lower in the osteoporosis group than that in the osteopenia group ( P < 0. 01). (2) 25-OHD, PTH, P1NP, β-CTX, and N-MID were significantly lower in the osteoporosis group than those in the normal bone mass (P < 0. 01). (3) There was no correlation between 25-OHD and BMD of the lumbar 1-4 and left femoral neck，and β-CTX (P > 0. 05 ) . The correlation coefficient between 25-OHD and N-MID was 0. 193 (P <0. 01). There was no significant difference of 25-OHD between the groups of different BMD (P > 0. 05). Conclusion The insufficient level of vitamin D and osteoporosis are popular in the elderly. The proportion of deficiency and serious deficiency of itamin D is large, providing certain reference data for the prevention and treatment of osteoporosis. We should pay attention to strengthen the education and prevention. The direct correlation between 25-OHD and BMD is not found. |
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