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| 两种唑来膦酸钠注射液治疗骨质疏松患者的临床研究 |
| The clinical study of two kinds of zoledronic acid injection in treating osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2017.07.015 |
| 中文关键词: 骨质疏松症 唑来膦酸钠注射液 VAS评分 骨代谢指标 骨密度 不良反应 |
| 英文关键词:Osteoporosis Zoledronic acid VAS scores Bone metabolic index Bone mineral density Adverse reactions |
| 基金项目:上海市科委资助项目（134119b1500) |
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| 中文摘要: |
| 目的 探讨两种不同的唑来膦酸钠注射液对骨质疏松症患者疗效差异。方法 回顾性分析我院从2013年1月至2015 年5月收治人院100例骨质疏松患者，并将其随机分为国产组和进口组，每组各50例，分别使用唑来膦酸钠注射液（国产）和唑来膦酸钠钠注射液（进口）进行静脉点滴治疗。观察两组患者治疗前及治疗一年后疼痛VAS评分、骨代谢指标、骨密度 (BMD)变化及使用后3天内不良反应发生情况。结果 ①VAS评分:两组骨质疏松症患者经过1年治疗以后，无论是国产组还是进口组，VAS评分有显著下降（P<0. 05),但进口组VAS下降幅度要优于国产组（P<0. 05);②骨代谢指标：两组血清中 25羟基维生素D较1年之前明显升高（P<0. 05)，而两组血清中I-CTX较之前明显下降（P<0. 05)，两组血清中骨钙素、25羟 基维生素D、I-CTX、PINP相比没有差异（P>0.05);③骨密度：两组骨密度中L1-L4、Torch值较治疗之前明显上升（P<0. 05), 而两组中L1-L4、Neck、Torch相比较，没有显著性差异（P>0. 05);④不良反应：无论是国产组还是进口组，不良反应以发热和肌肉酸痛为主，而进口组发生发热不良反应要比国产组低（P<0.05),其余不良反应，两组之间没有差异（P> 0.05)。结论 两种唑来膦酸钠注射液能缓解骨质疏松患者疼痛，提髙骨密度，减低骨折概率，但在副作用发生方面，进口组要优于国产组。 |
| 英文摘要: |
| Objective To investigate the therapeutic effect of two kinds of zoledronic acid injection on osteoporosis. Methods Retrospective analysis of 100 osteoporosis patients attended our hospital from January 2013 to May 2015，and they were randomly divided into domestic and imported zoledronic acid groups, each with 50 cases, and respectively used zoledronate sodium injection (domestic) and zoledronate sodium injection (imported) for intravenous treatment. VAS score, bone metabolic index, bone mineral density (BMD) and the incidence of adverse reactions within 3 days after treatment were observed before treatment and one year after treatment. Results 1) VAS score: After one year of treatment, the VAS scores of the two groups of osteoporosis patients decreased significantly (P <0. 05), and the VAS scores of the imported group was lower than that of the domestic group (P <0. 05)；2) Bone metabolic index： At one year, in both groups serum levels of 25-hydroxyvitamin D increased significantly (P < 0. 05) , while serum I-CTX levels decreased significantly (P <0. 05) compared with before treatment，but there were no significant differences in the serum levels of osteocalcin, 25 -hydroxyvitamin D, I-CTX and PINP between the two groups ( P > 0.05) ; 3) BMD：BMD of L1-L4 and Torch in the two groups were significantly higher after one year compared with before treatment (P < 0. 05) ,but there were no significant differences in L1-L4, Neck and Torch BMD between the two groups (P > 0. 05) ；4) Adverse reactions：in both groups，the most common adverse reactions were fever and muscle soreness, but the incidence of fever in the imported group was lower than that of the domestic group (P < 0. 05) , and between the two groups, there were no significant differences for other adverse reactions (P > 0. 05). Conclusion Both kinds of zoledronic acid injection can alleviate pain， increase bone density and reduce the probability of fracture in patients with osteoporosis，but in terms of side effects，the imported group was superior to the domestic group. |
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