中国骨质疏松杂志

血清胆红素水平与绝经后骨质疏松症相关性的临床分析

Clinical analysis of the correlation between serum total bilirubin level and postmenopausal osteoporosis

DOI：10.3969/j.issn.1006.7108.2017.07.018

英文关键词:Serum total bilirubin Postmenopausal osteoporosis Oxidative stress Body mass index Osteoporosis

基金项目:

作者	单位
王冀苏*	厦门大学附属中山医院老年医学部，福建厦门361000

摘要点击次数: 936

全文下载次数: 720

中文摘要:

目的探讨血清总胆红素在绝经后骨质疏松症发病机制中的作用。方法通过双能X线骨密度仪检查，将282例绝经后女性分为正常骨量组(n=93)和早期绝经后骨质疏松症组（n =61)、中期绝经后骨质疏松症组（n= 58)和晚期绝经后骨质疏松症组（n=70)。测定血清总胆红素和骨转换标志物水平，分析血清总胆红素与骨密度、骨代谢的关系。结果骨密度与年龄、I型胶原交联C-末端顶端肽（β-CTX)、甲状旁腺激素（parathyroid hormone，PTH)呈负相关，与体重指数（body mass index, BMI)、25羟基维生素D3(25(OH2)D3 )、血清总胆红素（total bilimbin，TBIL)呈正相关。Logistics回归分析显示，年龄、BMI、 TBIL、PTH、总I型前胶原N-末端肽与骨质疏松症的发生独立相关，而血清碱性磷酸酶（alkaline phosphatase,ALP)、β-CTX与绝经后骨质疏松无独立相关性。结论血清总胆红素水平下降为绝经后骨质疏松症的独立危险因素。

英文摘要:

Objective To investigate the effect of serum total bilirubin in the pathogenesis of postmenopausal osteoporosis. Methods By dual energy X-ray bone density instrument examination, a total of 282 postmenopausal women were divided normal bone mass group (n = 93) , early postmenopausal osteoporosis group (n =61)，middle postmenopausal osteoporosis group (n=58)，and late postmenopausal osteoporosis group (n =70). Serum total bilirubin and bone turnover markers were detected. The relationship between serum total bilirubin, bone mineral density, and bone metabolism was analyzed. Results Bone mineral density was negatively correlated with age, β-CTX, and PTH, but positively correlated with BMI, 25 (OH2) D3, and serum total bilirubin. Logistics regression analysis revealed that age, BMI, TBIL, PTH, and PINP were independently associated with the occurrence of osteoporosis, and ALP and β-CTX were not associated with postmenopausal osteoporosis. Conclusion The decrease of serum total bilirubin level is an independent risk factor of postmenopausal osteoporosis.

查看全文查看/发表评论下载PDF阅读器

关闭