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| 老年骨质疏松与颈动脉硬化的相关性研究 |
| Relationship between osteoporosis and carotid atherosclerosis in the elderly |
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| DOI：10.3969/j.issn.1006.7108.2017.07.019 |
| 中文关键词: 老年人 骨质疏松 动脉粥样硬化 骨密度 颈动脉内中膜厚度 |
| 英文关键词:Aged Osteoporosis Atherosclerosis Bone mineral density Carotid artery medial thickness |
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| 中文摘要: |
| 目的 探讨研究老年骨质疏松与颈动脉硬化的相关性。方法 将随机抽取的236名60岁以上的体检者作为研究对象，采用双能X线骨密度仪测定腰椎（L1-4)及股骨颈、Word’s三角、大转子的骨密度（bone mineral density,BMD)。采用高分辨率彩色超声探査颈动脉内中膜厚度（intima-media thickness，IMT)及斑块的情况。同时收集研究对象的基本资料，包括年龄、身高、体重、血钙、血脂等生化结果。将入选对象分为骨质疏松组和非骨质疏松组，颈动脉有斑块组和颈动脉无斑块组。结果 在骨质疏松组（114例）中，存在内膜增厚94例（82. 46%)，粥样斑块73例（64. 04% )，与非骨质疏松组（122名）比较，骨质疏松组在颈动脉内中膜增厚（IMT>0. 9 mm)及粥样斑块的发生率上均明显升高（P<0. 05) ;IMT增厚及斑块形成与骨量逐渐减少呈正相关，IMT、年龄、体重指数（body mass index，BMI)与骨质疏松发生显著相关（P <0. 05);性别分组比较得出，女性骨质疏松患者在颈动脉斑块中的发病率明显高于男性和非骨质疏松患者,其对比差异具有统计学意义（P <0.05)。结论 老年骨质疏松与动脉硬化存在密切联系；骨质疏松人群较非骨质疏松人群更易发生动脉粥样硬化病变，且女性骨质疏松患者的颈动脉硬化患病率明显高于男性。 |
| 英文摘要: |
| Objective To study the relationship between osteoporosis and carotid atherosclerosis in elderly patients. Methods A total of 236 over 60-year-old people were rand omly selected as the research subjects. Bone mineral density (BMD) of the lumbar spine (L1-4 ) , femoral neck, Word's triangle, and greater trochanter was detected using dual energy X-ray absorptiometry. High resolution color Doppler ultrasound was used to detect the carotid artery medial thickness (IMT) and plaque. The basic data were also collected, including age, height, body weight, serum calcium, blood lipids, and other biochemical result . The subjects were divided into osteoporosis group, non-osteoporosis group, and carotid plaque and carotid artery plaque group. Results In osteoporosis group (114 cases), there were 94 cases with intimal thickening (82. 46% )，and 73 cases with atherosclerotic plaque (64. 04% ). Compared with non-osteoporosis group (122 cases), the incidence of arterial intima-media thickening (IMT >0.9 mm) and atherosclerotic plaque increased significantly in osteoporosis group (P <0.05). There was a positive correlation between IMT thickening and plaque formation. IMT, age, and BMI were significantly correlated with the occurrence of osteoporosis (P < 0.05). The incidence of carotid atherosclerosis in women with osteoporosis was significantly higher than that in men with osteoporosis，and the difference between the two groups was statistically significant (P< 0. 05 ). Conclusion There is a close relationship between osteoporosis and atherosclerosis in the elderly. Atherosclerosis is more likely to occur in patients with osteoporosis than in non-osteoporosis. The prevalence of carotid atherosclerosis in women with osteoporosis is significantly higher than that in men. |
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