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| 铁蓄积、骨内血管与骨质疏松关系的研究进展 |
| Research advance in the relationship among iron accumulation, blood vessel in bone, and osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2017.07.024 |
| 中文关键词: 骨质疏松 铁蓄积 骨内血管 骨代谢 |
| 英文关键词:Osteoporosis Iron accumulation Intraosseous vessel Bone metabolism |
| 基金项目:国家自然科学基金（81572179);苏州市吴江区第一人民医院课题立项（院201615 );江苏省研究生创新计划（KYLX15_ 1227);苏州市科教兴卫青年项目（KJXW2015016);苏州科技计划项目（SYS201637) |
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| 中文摘要: |
| 铁蓄积可能是骨质疏松症发生的独立危险因素，许多研究表明铁蓄积可导致骨质疏松症的发生。目前，骨内血管是骨质疏松研究的热点，骨中特殊的血管亚型偶联了骨形成与血管形成。那么，铁蓄积能否通过影响骨内特殊血管亚型，进而引起骨量下降？本文就铁蓄积与血管的关系作一综述，探讨铁与骨内血管调控骨代谢的潜在意义。 |
| 英文摘要: |
| Iron accumulation is an independent risk factor of osteoporosis. Basic research shows that iron accumulation leads to osteoporosis. Currently, microvasculature in bone becomes a hot topic in osteoporosis research. A special vessel subtype is found in skeletal system, coupling angiogenesis and osteogenesis. Whether iron accumulation could cause low BMD by decreasing the special vessel subtype of vessel? This paper reviews the relationship between iron accumulation and blood vessel, and explores its potential clinical significance. |
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