| Objective To explore the factors related to osteopenia and osteoporosis in hospitalized type 2 diabetes mellitus (T2DM) patients. Methods Bone mineral density (BMD) of femoral neck (FN) and lumbar spine (L1-4) was measured using dual-energy X-ray absorptiometry (DXA). According to the BMD values, patients were divided into the groups of normal bone mass, osteopenia and osteoporosis (OP). SPSS software was used to compare the differences in age, gender, disease duration and biochemical indicators among the groups and to analyze the influencing factors of bone mineral density in T2DM. Results The groups of OP and osteopenia had older age, greater proportion of female, but lower BMI than that of the normal bone mass group (all P<0.05). Compared with the normal bone mass group, the OP group had longer duration for T2DM (P<0.05), lower levels of FPG, 2 HPG and glycosylated hemoglobin (P<0.05), and lower fasting c-peptide level (P<0.05). The osteopenia group had lower fasting insulin level than that of the normal bone mass group (P <0.05). In the logistic regression analysis, older age, lower FC-P level, lower HbA1C and lower BMI were significant predictors of T2DM combined with osteopenia and OP (P<0.05). Conclusion In hospitalized type 2 diabetes patients, the patients with older age, lower fasting c-peptide level and lower BMI are more likely to have osteopenia and osteoporosis. |