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| 维生素D与2型糖尿病患者握力的相关性研究 |
| The relationship between vitamin D status and grip strength in type 2 diabetes mellitus patients |
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| DOI：10.3969/j.issn.1006-7108.2017.08.015 |
| 中文关键词: 维生素D 糖尿病 2型 握力 |
| 英文关键词:Vitamin D Diabetes mellitus Type 2 Grip strength |
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| 中文摘要: |
| 目的 分析2型糖尿病患者的握力与维生素D的相关关系，探讨维生素D对握力的影响。方法 对126名2型糖尿病患者及121名健康人群进行研究，测定体重指数、股骨颈的骨密度、25（OH）D3水平，应用握力计测定双手握力。分析维生素D水平对握力的影响。结果 ①与正常对照组相比较：2型糖尿病患者维生素D水平偏低[男：（12.45±6.93）ng/mL对（16.25±6.73）ng/mL；女：（10.67±6.23）ng/mL对（13.29±6.24）ng/mL，均 P＜0.05]，握力低于正常对照组 [男：（35.34±8.86）kg对（37.67±10.27）kg；女：（23.30±5.95）kg对（35.34±8.86）kg，均P＜0.05]，女性股骨颈密度低于对照组 [（0.89±0.13）kg对（1.05±0.16）g/cm2，P＜0.05]；②126名糖尿病患者平均年龄58.7±11.7岁，男女比例65：61，男女患者分别按照25（OH）D3水平分为3组：严重缺乏组（＜10ng/mL）；缺乏组(≥10ng/mL而＜20ng/mL)；不足组(≥20ng/mL而＜30ng/mL)。男性患者中，与维生素D不足组相比较，严重缺乏组的骨密度降低，握力减少，差异具有统计学差异[(33.54±7.77)kg对（39.34±5.91）kg，P＜0.05]。女性患者中，与维生素D不足组相比较，维生素D缺乏组、严重缺乏组的骨密度减低，握力降低[(18.03±5.32)kg对(22.68±6.78)kg、（28.10±0.07）kg，P均＜0.05]；③多元直线逐步回归分析显示2型糖尿病患者中25（OH）D3与握力呈正相关（r=0.239，P=0.031），且独立于年龄、性别、股骨颈骨密度。结论 2型糖尿病患者维生素D水平同握力之间存在独立正相关。 |
| 英文摘要: |
| Objective To analyze the relationship between vitamin D status and grip strength in type 2 diabetes mellitus patients, and to investigate the effect of vitamin D on grip strength. Method One hundred and twenty-six patients with type 2 diabetes were enrolled. All subjects were measured for body mass index (BMI), bone mineral density (BMD) of the femoral neck and serum 25-hydroxyvitamin D (25(OH)D3) levels. Subjects were assessed for grip strength using a handgrip dynamometer. Linear regression analysis was used to determine the associations between vitamin D and grip strength. Results Compared with healthy controls, type 2 diabetes patients had lower 25-hydroxyvitamin D (25(OH)D3) levels (male: 12.45±6.93 ng/mL vs 16.25±6.73 ng/mL; female: 10.67±6.23 ng/mL vs 13.29±6.24 ng/mL, both P < 0.05), lower grip strength (male: 35.34±8.86 kg vs 37.67±10.27 kg; female: 23.30±5.95 ng/mL vs 35.34±8.86 kg, both P < 0.05), and females patients also had lower femoral neck BMD (0.89±0.13 g/cm2 vs 1.05±0.16 g/cm2, P < 0.05). Sixty-five male and 61 female diabetic patients were included in this study, and the average age was 58.65±11.67 years. According to the level of serum 25(OH)D3, the male and the female patients were divided into three groups: seriously deficient group (<10ng/mL), deficient group (≥10 ng/mL but <20ng/mL) and insufficient group (≥20 ng/mL but < 30ng/mL). In male patients, femoral neck BMD and grip strength in the seriously deficient group were lower than those of the insufficient group (33.54±7.77 kg vs39.34±5.91 kg, P < 0.05). In female patients, the femoral neck BMD and grip strength in the seriously deficient group and deficient group were lower than those of the insufficient group (18.03±5.32 vs 22.68±6.78 vs 28.10±0.07 kg, P < 0.05]. Multiple stepwise regression analysis showed that the level of 25 (OH)D3 was positively correlated with the grip strength in type 2 diabetes mellitus patients (r=0.239, P =0.031. Conclusion There was independent positive correlation between the level of vitamin D and the muscle strength in type 2 diabetes mellitus patients. |
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