| Osteoporosis is mainly related to menopause, aging and some diseases or drugs that affect bone metabolism, and is characterized by the imbalance of osteoblasts and osteoblasts function. Since bones relay on its blood vessels to complete the metabolism, the question is, if the microcirculation is impaired, whether it will affect bone metabolism and lead to osteoporosis? There are limited related reports in China in this area. International studies suggest that, from the cell molecular aspects, bone cells can produce angiogenic factors, and vascular endothelium can produce osteogenic factors; the growth of vascular network is regulated by signal factors produced by chondrocytes and bone cells; at the same time the blood vessels also affect the osteogenesis of new bone, and angiogenesis and bone formation are coupled by CD31 and Emcn antibody strongly positive H-type vascular endothelial cell. Animal experiments showed that the number of micro vessels and VEGF in osteoporotic rats was significantly decreased compared with the normal control group. Exercise-induced elevations in bone and marrow blood flow were associated with greater BV/TV. In clinical experiments, CT perfusion imaging and BMD examination of lumbar spine showed that microcirculation was positively correlated with bone mineral density, which indicated that microcirculation perfusion disorder was a potential cause of bone mineral density loss and acceleration of IDD (intervertebral disc degeneration). This article reviewed international research progress from molecular biology, animal experiments to clinical observation studies. |