|
| 肠道免疫功能与骨代谢的研究进展 |
| The research progress on intestinal immune function and bone metabolism |
| |
| DOI：10.3969/j.issn.1006-7108.2017.08.024 |
| 中文关键词: 肠道免疫 骨代谢 骨质疏松症 研究进展 |
| 英文关键词:Intestinal immune Bone metabolism Osteoporosis Research progress |
| 基金项目:甘肃省自然科学基金计划（1506RJZA048）；甘肃省中药现代制造工程研究院项目（YWW-2015049）；甘肃省中医药防治慢性疾病重点实验室开放基金项目（GSMBKY2015-07）；甘肃省财政厅基本科研业务课题（BH2010-428）；甘肃省中医药管理局科研课题(GZK-2016-17) |
|
| 摘要点击次数: 1167 |
| 全文下载次数: 613 |
| 中文摘要: |
| 肠道黏膜屏障有助于防止肠道内菌群紊乱，食物、化学药物等直接与黏膜裸露面接触，这对于疾病的发生尤为重要，其免疫功能对机体的健康作用越来越受到人们的重视。肠道免疫功能具有一般性的屏障作用，还能参与体液免疫和细胞免疫过程，在机体肠道内环境的调节中起重要作用。肠道免疫屏障构成复杂且受肠道菌群、饮食等的影响，能通过多种途径影响骨代谢，与骨质疏松症的发生关系密切，研究肠道菌群、免疫系统、骨代谢三者的关系，有助于进一步阐明肠道菌群通过调控宿主免疫系统来作用于机体骨代谢的机制，这可能对临床治疗骨质疏松症提供一种新的思维策略。本文将从几个方面阐述肠道免疫功能与骨代谢的研究进展。 |
| 英文摘要: |
| Intestinal mucosal barrier helps to prevent intestinal flora disorder and the direct contact of food and chemical drugs with the exposed surface of the mucosa. It is closely related to disease incidence, and more and more attention has been paid to the effect of its immune function on the health of human body. Intestinal immune system has the general barrier function, participates in the process of humoral immunity and cellular immunity, and plays an important role in the regulation of the intestinal environment. The intestinal immune barrier is complex and is affected by intestinal flora and diet, etc. It can affect bone metabolism through various channels, and is closely associated with the occurrence of osteoporosis. Studying the relationship between intestinal flora, immune system and bone metabolism is helpful for the further elucidation of the mechanism that intestinal flora affecting bone metabolism through regulating the host immune system. This may provide a new thinking strategy for the clinical treatment of osteoporosis. In this paper, we elaborated the research progress of intestinal immune function and bone metabolism from several aspects. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |