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| 锝[99Tc]亚甲基双膦酸盐治疗骨质疏松症的研究进展 |
| Research progress on Technetium [99Tc] methylene diphosphonate in the treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2017.08.025 |
| 中文关键词: 骨质疏松症 锝亚甲基双膦酸盐 治疗 |
| 英文关键词:Osteoporosis, Technetium [99Tc] methylene diphosphonate, Treatment |
| 基金项目:西南医院军事医学科技创新计划（SWH2016JCZD-06） |
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| 中文摘要: |
| 骨质疏松症是一种全身性代谢性骨骼疾病, 临床主要表现为骨骼疼痛、骨密度降低和骨折危险性增加，严重影响患者的生活质量。现阶段我国老年人中骨质疏松患病比例超过50% 以上，其中骨折发生率接近1/3。双膦酸盐是目前治疗骨质疏松的主要药物之一，因其具有强有力的破骨细胞抑制作用，临床应用广泛，而锝（99 Tc）亚甲基双膦酸盐( technetium methylenediphosphonate，99Tc-MDP) 注射液，商品名云克，是我国自主研制成功的新药，其主要成分是锝经氯化亚锡还原后与亚甲基双膦酸盐形成的螯合物，具有清除人体自由基、保护超氧化物歧化酶活力、抑制病理复化物的产生、抑制白细胞游走、降低胶原酶对软骨组织的破坏并修复破骨作用。可抑制骨吸收、改善骨质量、提高各个部位的骨密度、减低骨折风险，促进成骨，缓解骨痛。近年来已广泛应用于骨质疏松症的治疗，并已取得了较好的效果，且使用安全，无明显的副作用。本文对近年来云克应用于骨质疏松症的动物实验、临床疗效及安全性研究进行综述。 |
| 英文摘要: |
| Osteoporosis is a systemic metabolic bone disease, and its main clinical manifestations are bone pain, decreased bone mineral density and increased fracture risk, which affect the quality of life of patients. At present, the prevalence rate of osteoporosis in elderly people is greater than 50% in China, and the incidence of osteoporotic fracture is approximately 1/3. Bisphosphonates is one of the main drugs for the treatment of osteoporosis at present, because of its strong effects in inhibiting bone resorption. Technetium [99Tc] methylenediphosphonate injection (99Tc-MDP, commodity name Yunke), is a new drug independent researched and developed in China. The main ingredient is a chelated product by stannous chloride reduction of technetium [99Tc] and methylenediphosphonate. It has the functions of clearing free radicals of human body, protecting the activity of superoxide dismutase, suppressing the generation of pathological complex, inhibiting the migration of leukocytes, reducing the destruction of cartilage by collagenase and promoting the healing of bone. It can also inhibit bone absorption, improve bone quality, improve bone mineral density at various sites, reduce fracture risk, promote osteogenesis and relieve pain, and has an extensive clinical application. In recent years it has been widely used in osteoporosis treatment, as an effective and safe therapy without obvious side effects. In this article, recent animal experiments and studies on the clinical efficacy and safety of Yunke in treating osteoporosis have been reviewed. |
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