| With the increase in life expectancy, the number of patients with musculoskeletal system diseases is growing. At the same time, more and more domestic and overseas scholars focused on the research of sarcopenia and osteoporosis. Sarcopenia is defined as the decrease of muscle mass and muscle strength or muscle function with aging. Osteoporosis is characterized by a decrease in bone mass as well as a deterioration of the bone architecture resulting in an increased risk of fracture. Sarcopenia and osteoporosis are pathological conditions that endanger the health of the elderly and significantly reduce their quality of life. People suffer from sarcopenia have worse immune function and activity of daily living, and have higher risk of infection, falls, disability and death than healthy people. People with osteoporosis also have higher risk of falls, fracture and disability. Sarcopenia and osteoporosis are closely related and interact with each other, but the mechanism is quite complex. It includes the effects of mechanical load produced by muscle contraction on skeletal mechanical force, and the biological mechanism of complex and precise endocrine regulation between muscle and bone. There are many common risk factors and pathogenesis for sarcopenia and osteoporosis. If we can interpose in advance by exercise intervention, nutritional instruction, and drug therapy for them, the disease progression could be delayed and the prognosis could be improved. This paper reviews the relationships between the two diseases and the research progress by summarizing both domestic and foreign research on the concept, pathogenesis, clinical manifestation, evaluation criteria, intervention and treatment. |