| Objective To observe the effect of atorvastatin combined with aspirin on bone mineral density and bone biochemistry and metabolism in postmenopausal women with coronary heart disease. Methods Sixty patients with postmenopausal coronary heart disease were divided into treatment group (n=30) and control group (n=30) according to a random number table method. Patients in the control group and the treatment group received aspirin and atorvastatin plus aspirin, respectively, for 12 months. Bone mineral density (BMD) of the lumbar spine 1-4 (L1-4), femoral neck, femur greater trochanter, and total hip, and the levels of serum calcium (Ca), phosphorus (P), type 1 procollagen N-terminal propeptide (P1NP), and type 1 collagen carboxy terminal degradation products (β-CTX) were tested and recorded. Results After 6 months and 12 months of the treatment, BMD of the two groups increased in different degrees. BMD of L1-4, femoral neck, femur greater trochanter, and total hip increased significantly (P<0.05). After 6 months and 12 months of the treatment, the levels of Ca, P, β-CTX, and P1NP in the two groups changed to different degrees. Ca, P, and β-CTX increased significantly (P<0.05). The changes in the treatment group was significantly more than those in the control group (P<0.05). Conclusion Atorvastatin combined with aspirin improves BMD and bone biochemical and metabolic status in women with postmenopausal coronary heart disease. |