| Objective To evaluate the therapeutic effect of flavonoids drynaria fortunei combined with whole body vibration (WBV) on osteoporotic vertebral compression fractures. Methods 129 osteoporotic vertebral compression fractures were included in this study. They were randomly assigned to flavonoids drynaria fortunei group, systemic vibration therapy group, and combination therapy group. All the patients received PVP treatment. In addition, patients in each group received flavonoids drynaria fortune, systemic vibration therapy, and flavonoids drynaria fortunei combined with systemic vibration therapy, respectively, for 6 months. The pain VAS score, bone mineral density (BMD) of the lumbar and hip, serum alkaline phosphatase (ALP), carboxy-telopeptide of type I collagen (β-CTX), calcium (Ca), and phosphorus (P) were compared. The incidence of adverse reactions after medication were compared. Results The VAS scores of patients in 3 groups relieved after 6-month treatment (P<0.05), and the scores of patients in combination therapy group was much lower than those in flavonoids drynaria fortunei and systemic vibration therapy groups (P<0.05). After 6 months of the treatment, BMD in 3 groups significantly improved (P<0.05). The serum ALP, β-CTX, P, and Ca changed significantly after the treatment (P<0.05), and all indexes in combination group were better than those in flavonoids drynaria fortunei group and systemic vibration therapy groups (P<0.05). There was no statistical difference in the incidence of adverse drug reaction among 3 groups (P>0.05). Conclusion The combination of flavonoids drynaria fortunei and whole body vibration in the treatment of osteoporotic vertebral compression fractures is effective and safe, and suitable for wider clinical application． |