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| BMC/体重指标评价骨质疏松的探索 |
| BMC/body weight index for osteoporosis evaluation |
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| DOI：10.3969/j.issn.1006.7108.2017.10.001 |
| 中文关键词: BMC 体重标准化 骨质疏松 |
| 英文关键词:BMC Weight standardization Osteoporosis |
| 基金项目: |
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| 中文摘要: |
| 多年来使用面积骨密度（g/cm2)诊断骨质疏松，然而它属于不完全标化，必然会导致大体重（大骨骼)漏诊及小体重（小骨髂）误诊骨质疏松的弊病。本研究发现体重是决定骨矿含量（Bone mineral content，BMC)的重要因素，骨的力学负荷的源泉是体重，流调分析中发现影响骨量的34个因素中体重贡献最大，一些国内外文献证明体重与BMC的相关性髙（体重与全身 BMC的相关性髙达0. 704~0. 872)，提示用体重标准化BMC是适合的。从儿童到青年成人的全身及桡骨远端1/3两个部位的体重标准化BMC值是个不变的常数。使用体重标准化BMC诊断骨质疏松，则可能避免用g/cm2指标引起的大骨者漏诊及小骨者误诊骨质疏松的缺点。而且儿童和成人还可能共用一个正常参考值。 |
| 英文摘要: |
| Areal bone mineral density (aBMD) has been used for osteoporosis diagnosis for many years，but it unavoidably leads to missed cases in patients with large bones and misdiagnosed cases in those with small bones. Body weight is regarded as an important determinant of bone mineral content (BMC) in recent years because weight is the source of mechanical loading to bone. Epidemiological studies have shown that weight made the largest contribution to bone mass among 34 predictors. Publications from China and overseas have shown close association between weight and BMC (up to 0. 704 -0. 872 for the association between body weight and whole body BMC)，and the association was stronger than that of BMD，suggesting that weight standardized BMC is suitable. It was also found that BMC/body weight index (wBMC) is an invariable constant from children to young adults for whole body and one-third of distal radius. Applying wBMC for osteoporosis diagnosis may avoid misdiagnosis in individuals with small bones and missed diagnosis in those with large bones using aBMD. Furthermore，children and adults can use the same normal reference value. |
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