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| 多囊卵巢综合征患者血清25(OH)D3与糖脂代谢的相关性研究 |
| Research on the relationship between serum 25 hydroxyvitamin D3 and glucolipid metabolism in patients with polycystic ovary syndrome |
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| DOI：10.3969/j.issn.1006.7108.2017.10.008 |
| 中文关键词: 多囊卵巢综合征 肥胖 超重 25羟维生素D3 胰岛素抵抗 |
| 英文关键词:Polycystic ovary syndrome Obesity Overweight 25-hydroxyvitamin D3 Insulin resistance |
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| 中文摘要: |
| 目的 观察多囊卵巢综合征（Polycystic ovary syndrome，PCOS)患者血清25羟维生素D3[25 hydroxyvitamin D，25( OH) D3 ]水平，探讨PCOS患者维生素D对糖脂代谢的影响。方法 选取2015年12月至2016年9月我院住院及门诊新诊断的70 例PCOS患者及70例年龄及体重指数均匹配的健康对照者。根据BMI分为四组:超重/肥胖PCOS组（OW/OB + PCOS组）36 例，非肥胖PCOS组（PCOS组)34例，超重/肥胖对照组（OW/OB组）37例，非肥胖对照组（NC组）33例。测定血清25(OH) D3、空腹血糖（FPG)、总胆固醇(TC )、甘油三酯（TG)、低密度脂蛋白胆固醇（LDL-C)和髙密度脂蛋白胆固醇（HDL-C)、糖化血红蛋白（HbAlc)、空腹胰岛素（Fins)、性激素水平，采用稳态模型TOMA-IR指数评估胰岛素抵抗（Insulin resistance，IR)程度。 结果 ①OW/OB +PCOS组25(OH)D3、HDL-C均较OW/OB组显著降低，而TG、Fins、HOMA-IR均较OW/OB组显著增髙（P < 0. 05);②OW/OB +PCOS 组 25(OH)D3、HDL-C 均较 PCOS 组显著减低、而 TG、Fins、HOMA-IR 均显著增髙（P <0. 05) ；③PCOS 组25(OH)D3、HDL-C较NC组均显著减低，而TG、Fins、HOMA-IR、LH、TES则均显著增髙（P < 0. 05);④相关分析示25(OH) D3 水平与 BMI、FINS、HOMA-IR、TG 呈负相关（r = -0. 208，P =0.034; r = -0.918，P =0.000; r = -0. 799，P =0.000; r =-0.683，P = 0.002)，与HDL-C呈正相关(r =0.585，P =0.001)。结论 PCOS患者血清25(OH)D3水平减低与肥胖和脂代谢紊乱密切相关。 |
| 英文摘要: |
| Objective To observe the levels of serum 25 hydroxyvitamin D3 [ 25 (OH) D3] in patients with polycystic ovary syndrome (PCOS) and to investigate the association of vitamin D with glucose and lipid metabolism in PCOS patients. Method A total of 70 patients with newly-diagnosed PCOS from January 2015 to September 2016 were enrolled，and 70 age and body mass index (BMI) - matched healthy controls were also enrolled in the study. According to BMI，the subjects were divided into four groups ： Overweight/obese PCOS group (OW/OB + PCOS group，n =36)，non-obese PCOS group (PCOS group，n =34)， overweight/obese control group (OW/OB group，n = 37)，non-obese control group (NC group n =33). Serum 25 (OH) D3 and glycosylated hemoglobin ( HbAlc)，fasting blood glucose (FPG)，fasting insulin (FINS)，total cholesterol ( TC)，triglyceride (TG)，low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) and sex hormone levels were determined. The IR index was calculated by the homeostasis model assessment method (HOMA-IR). Results ①Compared with those in OW/OB group，patients in OW/OB + PCOS group had decreased 25( OH) D3 and HDL-C (P <0. 05)，but elevated TG，Fins，HOMA-IR，LH and TES levels(P <0. 05).② Compared with those in PCOS group，patients in OW/OB + PCOS group had reduced 25 ( OH) and HDL-C ( P <0. 05)，but elevated TG, FINS, HOMA-IR, LH and TES levels ( P <0. 05).③ Compared with those in NC group，patients in POCS group had significantly decreased 25 (OH) D3 and HDL-C (P < 0. 05)，but significantly increased TG，FINS，HOMA-IR，LH and TES levels (P < 0. 05).④ Correlation analysis showed that 25 ( OH) D3 levels were negatively correlated with BMI，FINS，HOMA-IR and TG (r = -0. 208，P =0. 034 ； r = -0. 918，P =0. 000 ； r =- 0. 799，P =0. 000 ； r = -0. 683，P =0. 002)，and was positively correlated with HDL-C (r =0. 585，P =0. 001). Conclusion The decrease of serum 25(OH) D3 level in patients with PCOS is closely related to obesity and lipid metabolism disorder. |
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