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| 绝经后女性雌二醇水平与膝骨性关节炎的相关性研究 |
| The correlation analysis of estradiol levels and knee osteoarthritis in postmenopausal women |
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| DOI：10.3969/j.issn.1006.7108.2017.11.009 |
| 中文关键词: 绝经后女性 膝骨性关节炎 雌二醇 |
| 英文关键词:Postmenopausal women Knee osteoarthritis Estradiol |
| 基金项目:济宁市科技发展计划项目（济科字[2016]56号-94) |
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| 中文摘要: |
| 目的 研究绝经后女性雌二醇水平与膝骨性关节炎（knee osteoarthritiS，KOA)发病严重程度的相关性。方法 选择121 例绝经后女性膝骨性关节炎患者作为试验组，根据膝关节X线平片Kellgren-Lawrence(K-L)分级将其分为轻度组（35例）、中 度组(44例）及重度组(42例）。选择35名健康查体的正常绝经后女性作为对照组。所有受试者均采集空腹血液测定血清雌二醇（estradiol，E2)、空腹血糖（fasting blood glucose，FBG)、总胆固醇(triglyceride，TC )、低密度胆固醇(low density lipoprotein cholesterol，LDL-C)、高密度胆固醇（high density lipoprotein cholesterol，HDL-C)、甘油三酯（triglyceride，TG);试验组人员采用联影X射线成像系统（uDR)行膝关节平片，采用飞利浦3. 0 T磁共振Ingenia Ⅱ行膝关节磁共振T2 mapping成像，并用WOMAC 评分量表行膝关节功能评定。所得数据采用SPSS19.0软件进行统计分析。结果（1)绝经后KOA组的E2水平显著低于正常组的E2水平(P =0.000)。（2)KOA组随病变严重程度增加，血清E2水平下降，WOMAC评分及T2值升高;血清E2水平与WOMAC评分及T2值均呈显著负相关(r = -0.651、-0.501)。结论 绝经后女性KOA患者雌二醇水平与KOA严重程度呈负相关。 |
| 英文摘要: |
| Objective To explore the correlation between of serum estradiol level and severity of osteoarthritis ( OA) in postmenopausal females. Methods A total of 121 postmenopausal females with OA were divided into mild group (n =35)， moderate group ( n =44)，and severe group ( n =42)，according to K-L grades of the knee joint. Thirty-five normal postmenopausal women who underwent physical examination were selected as control. Fasting blood were extracted from all the subjects to detect E2，FBG，TC，LDL-C，HDL-C，and TG. In the experimental group，X-ray radiography of the knee was performed with uDR. MR T2 - mapping imaging of the knee was performed with PHILPS 3. 0T Ingenia II. The WOMAC scale for the knee joint function was assessed. The data were analyzed with a SPSS 19. 0 software. Results (1) The level of E2 in postmenopausal KOA group was significantly lower than that in normal group (P =0. 000). (2) In KOA group，with the severity of the lesion，serum E2 levels decreased，and WOMAC scores and T2 values increased. The levels of serum E2 were negatively correlated with WOMAC scores and T2 values ( r = -0.651 and -0.501，respectively). Conclusion Estradiol levels in postmenopausal KOA patients were negatively correlated with the severity of KOA. |
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