|
| 山东沿海地区成年女性骨密度调查及骨量分析 |
| The investigation and analysis of bone mineral density in women in Shandong coastal area |
| |
| DOI：10.3969/j.issn.1006.7108.2017.11.021 |
| 中文关键词: 骨密度 骨质疏松 数据库 女性 交叉校正 |
| 英文关键词:Bone mineral density Osteoporosis Database Women Cross correction |
| 基金项目:山东省医药卫生科技发展计划项目（2013ws0037) |
|
| 摘要点击次数: 677 |
| 全文下载次数: 535 |
| 中文摘要: |
| 目的 确立山东沿海地区成年女性骨密度（bone mineral density，BMD)的正常参考范围，建立诊断成年女性骨质疏松 (osteoporosis，OP)的多骨骼部位BMD参考值，并考察其应用。方法 测量25 ~ 35岁健康成年女性的BMD值，交叉校正烟台 Lunar i型与青岛Lunar NT型双能X射线骨密度仪（dual energy X-ray absorptiometry，DXA)，得到腰椎（L2-4 )正位和左侧髓部 (股骨颈、大转子、Ward三角区)6个骨骼区域的线性回归方程，并矫正烟台、青岛两地的BMD数据；比较烟台、青岛两地区校正后的BMD值，找出最佳拟合的方程，建立山东沿海地区正常成年女性的BMD数据库；利用该数据库检测当地中老年女性 OP的发病率，同时比较新建的数据库与仪器自备数据库的适用性。结果 （1)烟台Lunar i型与青岛Lunar NT型DXA测得的BMD值存在明显的线性关系。（2)6个骨骼区域腿D随年龄的变化，用3次回归模型模拟得到山东沿海地区正常成年女性的BMD数据库，结果显示BMD峰值骨量在20 ~40岁，从40岁之后开始直线下降。（3)通过本文建立的BMD数据库，考察当地2005-2012年体检的女性(50 ~89岁）发现，山东沿海地区中老年女性OP发病率随年龄逐年增加，但低于其他地区OP发病率。与Lunar i型DXA自身配备的数据库相比，本研究建立的数据库比Lunar i型DXA自配数据库检出的OP发病率髙。结论 本研究建立的参考数据库适用于山东沿海地区，可作为当地诊断OP的依据。 |
| 英文摘要: |
| Objective To establish and evaluate the bone mineral density (BMD) reference database of multiple skeletal regions，which would be useful for diagnosis of osteoporosis (OP) in women. Methods Healthy females aged 25 - 35 years were selected. BMD of the lumbar spine (L2，L3，and L4)，the left hip (femoral neck，Ward’s triangle，and the greater trochanter was measured using dual-energy X-ray absorption (DXA，Lunar i and Lunar NT，USA，respectively). The calibration equations were established. BMD between women in Qingdao and in Yantai was compared before and after the calibration. The best fitting model equations were found and the reference database was established. Prevalence of OP was analyzed according to the database. Results (1) BMD result examined with Lunar i and Lunar NT showed significant linear relationship. (2) BMD after calibration in 6 skeletal regions showed change with aging. BMD reference database of women in Shandong ’ s coastal area was established by cubic regression equation. The peak BMD appeared at 20 - 40 years old and followed by a linear decrease after 40 years old. (3) Based on this database，the prevalence of OP increased with age in women aged from 50 to 89 who had medical examination from 2005 to 2012. The prevalence was lower than other cities. The detecting rates of OP were higher than that provided by the Lunar i reference database. Conclusion This study establishes the BMD reference database in women in Shandong coastal area，which can be used as reference standard for OP diagnosis in the region. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |