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| 南宁地区20899名壮族、汉族正常人群峰值骨量和年龄相关骨丢失的临床意义 |
| Clinical significance of peak bone mass and rate of bone loss in 20899 normal people of Zhuang and Han nationalities in Nanning area |
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| DOI：10.3969/j.issn.1006.7108.2017.11.022 |
| 中文关键词: 骨丢失率 峰值骨量 骨质疏松 骨折风险 流行病学 |
| 英文关键词:Peak bone mineral density Rate of bone loss Osteoporosis Risk of fractures Epidemiology |
| 基金项目:R681 |
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| 中文摘要: |
| 目的 探讨南宁地区壮族、汉族正常人群骨密度（bone mineral density，BMD)、峰值骨量（peak bone density，PBD)以及随增龄骨丢失率（rate of bone loss，RBL)的规律及临床意义。方法 使用美国Hologic公司生产的双能X线吸收仪（dual energy X-ray absorptiometry，DAX)，对南宁地区壮族、汉族正常体检人群的20899名的腰椎L1-4、左股骨颈上段BMD进行测定，按检测不同部位、性别、年龄分组统计出PBD的均值±标准差和RBL(%)。参照WHO的规定，对≥50岁男性和绝经后女性与本数据库人群中同性别、同部位PBD比较，-2.5 |
| 英文摘要: |
| Objective To investigate the clinical significance of bone mineral density (BMD)，peak bone density (PBD)，and the rate of bone loss (RBL) in normal people of Zhuang and Han nationalities of Nanning area. Methods BMD of the lumbar vertebrae L1 - L4 and the left femoral neck was measured in 20899 cases of normal people in Nanning area by using dual energy X- ray absorptiometry (DAX，Hologic，USA). PBD and RBL were calculated according to different locations，gender，and age. According to the WHO criteria，compared with the local PBD of our database， -2. 5 < T < -1.0 was diagnosed as bone loss and T≤- 2. 5 was diagnosed as osteoporosis，in males over 50 years old and postmenopausal women. Results (1) PBD appeared at the 25 -27 years old. In the lumbar vertebrae，it was 1. 066 ±0. 153 in males and 1. 025 ±0. 095 in females，respectively. In the left femoral neck，it was 0. 920 ±0. 136 in males and 0. 796 ±0. 132 in females，respectively. (2) BMD in females was stable before 47 years old. It accelerated to loss after menopause，particularly in the lumbar vertebrae，with annual RBL of 1. 13% - 2% . RBL increased gradually with age in males. The annual loss rate was 0. 21% -0. 68%. RBL at the left femoral neck was always higher than that at the lumbar vertebrae. (3) Referred to the local database，the detection rate of osteoporosis in males was 3. 1% in the spine，9. 47% in the left femoral neck，respectively. It was 48. 8% in the spine，5. 02% in the left femoral neck，respectively， in females. Conclusion The risk of osteoporotic fractures in the elderly women is significantly higher than that in men. Women are more likely to suffer from osteoporotic fractures in the spine，but men are more likely to suffer from that in the femoral neck. |
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