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| 基于PubMed数据库对miR与骨代谢相关信号通路的文献研究 |
| Literature study on miR and bone metabolism related signaling pathway based on PubMed database |
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| DOI：10.3969/j.issn.1006.7108.2017.11.027 |
| 中文关键词: PubMed数据库 小分子RNA 骨代谢 信号通路 骨质疏松 |
| 英文关键词:PubMed database miR Bone metabolism Signaling pathway Osteoporosis |
| 基金项目:甘肃省自然科学基金计划（1506RJZA048)；甘肃省中药现代制造工程研究院项目（YWW-2015049);甘肃省中医药防治慢性疾病重点实验室开放基金项目（GSMBKY2015-07)；甘肃省财政厅基本科研业务课题（BH2010-428)；甘肃省中医药管理局科研课题 (GZK-2016-17) |
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| 中文摘要: |
| 目的 研究miR通过信号通路对骨代谢的调控机制。方法 通过检索PubMed数据库2000年-2016年期间miR与骨代谢相关信号通路的文献，将相关miR的功能进行分析并予以归类。结果总共检索到相关文献949篇，符合纳人及排除标准的文献有140篇，分析显示miR与骨代谢相关信号通路的文献研究主要以经典的信号通路为主，miR对骨质疏松的作用机制主要表现在对成骨细胞的影响、对破骨细胞的影响、对骨髓间充质干细胞的影响及对钙盐代谢的影响4个方面。结论 miR通过信号通路对骨代谢的调控具有重要的意义，其可作为诊断与治疗骨质疏松症的血清潜在标志物。 |
| 英文摘要: |
| Objective To study the regulation mechanism of miR on bone metabolism through signaling pathway. Methods The literatures of miR and bone metabolism related signaling pathways were searched from PubMed database from 2000 to 2016. The function of the related miR was analyzed and classified. Results A total of 949 articles were retrieved and 140 articles were included according to the inclusion and exclusion criteria. It showed that main studies of miR were related to classical signal pathways. The mechanism of miR on osteoporosis included its impact on osteoblasts，the impact on osteoclasts， the effect on bone marrow mesenchymal stem cells，and the effect in calcium metabolism. Conclusion MiR plays an important role in the regulation of bone metabolism through signaling pathways. It can be used as a potential serum marker for the diagnosis and treatment of osteoporosis. |
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