| Objective To investigate the relationship between serum tumor markers and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM). Methods Study participants were T2DM patients who were recruited from the Department of Endocrinology of the First Affiliated Hospital of Shihezi University from February 2014 to December 2015. According to the results of dual energy X-ray absorptiomentry BMD examination, the subjects were divided into T2DM and normal bone mass group, T2DM and Osteopenia group, T2DM and osteoporosis group, respectively, to compare tumor markers between the groups of and analyze the relationship between relevant factors and bone mass. Results 1.Compared with the normal bone mass group, the osteopenia group had higher levels of fasting plasma glucose (P < 0.05). Compared with the normal bone mass group, the osteoporosis group had higher levels of fasting plasma glucose (P <0.01). Compared with the normal bone mass group, the osteoporosis group had higher levels of HbAlc (P <0.05). Compared with normal bone mass group, fasting insulin, insulin resistance and insulin secretion in the osteopenia group and the osteoporosis group were lower (P <0.01). 2. Compared with the normal bone mass group, the osteoporosis group had higher CA199 (P <0.01). 3. There was a negative correlation between femoral neck BMD and serum CA199 (r=–0.192, P <0.01). 4. With CA199 as the dependent variable and age, weight, duration of diabetes, BMI, fasting plasma glucose, HbA1c, insulin resistance, insulin secretion and femoral neck BMD as independent variables for multiple linear regression analysis, femoral neck BMD (P =0.021, t=–2.328) entered into the regression equation,Y=34.674–22.65X. Conclusion Serum CA199 increased in patients with type 2 diabetes mellitus and osteoporosis. In patients with type 2 diabetes, the lower bone mineral density, the higher the level of CA199. |